the influence of glycosaminoglycans (gag) on collagen fibrillogenesis in vitro was investigated. gag and collagen were isolated from the liver of rats treated with carbon tetrachloride at various time intervals (3-16 weeks). it was found that gag obtained from the fibrotic liver accelerated collagen fibril formation. this effect was more evident in a solution of type i collagen than type iii co...

abstract isolated tuberculosis (tb) liver abscesses have rarely been documented in the literature.this report describes the challenging diagnosis of primary liver tb. we report on the case of a 10-year-old girl with down syndrome, who had symptoms of fever and chills, anorexia and intermittent vomiting. the ultrasound and computed tomography (ct)revealed multiple abscess-like lesions in the liv...

Background: The renin-angiotensin system has an important role in hepatic inflammation and fibrosis. Renin-angiotensin system blockade by angiotensinconverting enzyme (ACE) inhibitors provides some protective effects against hepatic fibrogenesis. Captopril as an ACE inhibitor can decrease inflammatory mediators and attenuate hepatic fibrosis in the livers of bile duct ligated (BDL) rats. Object...

Isolated hepatic tuberculoma is localized hepatic tuberculosis (TB) without bile duct involvement, which presents as solitary or multiple nodular mass lesion of liver mimicking a neoplastic lesion in radiological evaluation. Clinical presentation and biochemical tests for liver functions show non-specific abnormality, which is not helpful for diagnosis. As the treatment, modality of isolated he...

Objective(s): Liver transplantation is the most important therapy for end-stage liver disease and ischemia reperfusion (I/R) injury is indeed a risk factor for hepatic failure after grafting. The role of miRNAs in I/R is not completely understood. The aim of this study was to investigate the potential protective role of the mesenchymal stem cells (MSCs) and ischemic pr...

diffuse hepatic inltration is an unusual form of hodgkin's disease (hd). its manifestation as progressive hepatitis or with hepatic failure is even rarer and can be difcult to diagnose. we aim to describe an unusual case of liver failure due to hd. a middle-aged woman with a 10 month history of daily febrile episodes, constitutional symptoms and strikingly high levels of serum ferritin was admi...

conclusions no evidence-based guidelines exist on the use of analgesics in patients with liver disease and cirrhosis. as a result pain management in these patients generates considerable misconception among health care professionals, leading under-treatment of pain in this population. providing concrete guidelines toward the administration of these agents will lead to more efficient and safer p...

chronic granulomatous disease (cgd) is a rare inherited disorder characterized by inability of phagocytes to generate oxygen radicals needed for intracellular killing of phagocytic microorganisms. we report a 2.5-year-old iranian female with multiple liver abscesses. she was admitted in surgical ward because of abdominal pain and fever for one month duration that had no response to conventional...

background budd-chiari syndrome (bcs) is defined as hepatic venous outflow obstruction (hvoo). bcs is an uncommon, life-threatening liver disorder. this study describes the clinical and etiological characteristics in addition to the long-term outcome of bcs in a single referral center in tehran, iran. methods we reviewed long-term outcome of patients who were diagnosed with bcs between 1989 and...

background: this study was carried out to observe the radioprotective effects of rosemarinus officinalis leaves extract (roe) against radiation-induced histopathological alterations in liver of mice. materials and methods: adult swiss albino mice were exposed to 6 gy gamma radiation in the presence (experimental) or absence (control) of roe to study the qualitative and quantitative alterations ...