We read with interest the recent report by Garner et al. [l], in which anti-E was detected early in pregnancy solely through the use of enzymetreated red blood cells (RBC). The serological reactivity of this anti-E changed dramatically during pregnancy; the antibody became detectable by the indirect antiglobulin test, and at 37 weeks’ gestation had a titer of 512. Delivery at 40 weeks’ gestatio...

BACKGROUND About 85.3% of hemolytic disease of the newborn (HDN) is caused by maternal-fetal ABO blood group incompatibility. However, there is currently no recommended "best" therapy for ABO incompatibility during pregnancy. OBJECTIVES To systematically assess the safety and effectiveness of oral Chinese herbal medicine (CHM) for preventing HDN due to ABO incompatibility. METHODS The proto...

Frequency of Rhesus and ABO blood groups was determined in 3012 mothers. The blood groups in order of frequency were B, O, A and AB. Only 6.2% mothers were rhesus negative. ABO haemolytie disease of the newborn (HDN) accounted for 15.7% and Rh-HDN for 12.7% of 306 neonate admitted with Jaundice. No significant difference was found in two groups when levels of serum bilirubin, exchange transfusi...

INTRODUCTION Hemolytic disease of the newborn was first described in the medical literature 1609, when it was diagnosed in one French housewife. In 1932 Diamond and colleagues described the mutual relationship of fetal hydrops, jaundice, anemia and erythoblastosis, which was later called fetal erytroblastosis. Hemolytic disease of the newborn (HDN) in the strict sense is considered disease whos...

OBJECTIVE The direct antiglobulin test (DAT) is an important tool for identification of haemolytic disease of the newborn (HDN) caused by erythrocyte immunization. Although this test has been used for decades, accurate insights into its diagnostic properties and optimal use in the diagnosis of HDN are limited. We aimed to gain more insight into the diagnostic properties of the DAT for HDN by co...

Materials and Methods: This two-year retrospective study of 1800 jaundiced term-neonates studied 355 cases due to ABO incompatibility divided into two groups: with and without hemolytic disease. Relation of laboratory parameters and immunohematological tests to severity of disease were studied. We did not analyze the maternal antibody titer or elusion test, and this was a limitation of the stud...

Blueberry muffin rash is a characteristic multiple bluish skin nodules associated with perinatal infection, severe and chronic anemia, and neoplastic infiltrative diseases. We present an unusually severe case of hemolytic disease of the newborn. He required exchange transfusions for several times. The complete work up led to the diagnosis of anti-Cw. The skin lesion regressed spontaneously with...