22:1-15. 8. Thomas TC, Rollins SA, Rother RP, et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv. Mol Immunol. 1996;33:13891401. 9. Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L. Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat Biotechnol. 2007;25:1256-1264. 10. Hillmen P...

BACKGROUND Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and are present in about 40-50% of patients with severe aplastic anemia. Flow cytometry has allowed for sensitive and precise measurement of glycosylphosphatidylinositol-anchor protein-deficient red blood cells and neutrophils in severe aplastic anemia. DE...

Erythrophagocytosis refers to the removal of old and damaged red blood cells by leukocytes and macrophages. Observation of erythrophagocytosis in peripheral blood smear is a rare phenomenon that is mostly observed in paroxysmal cold hemoglobinuria and sporadically in some other pathological conditions. Here, we report a case of erythrophagocytosis by monocyte in peripheral blood of a patient wi...

Several observers have directed attention to the frequent occurrence of vasomotor disturbances in patients with paroxysmal hemoglobinuria, and a few (1, 2, 3, 4, 5) have suggested that these disturbances are of importance in the pathogenesis of the disease. The purpose of this communication is to present observations on a patient with paroxysmal hemoglobinuria which demonstrate that the sympath...

One Holstein cow housed with 21 other cows exhibited clinical signs of pyrexia, anorexia and diarrhea along with severe hemoglobinuria. Hematological and biochemical analyses conducted before and after antibiotic therapy indicated severe hemolytic anemia and disruption of hepatic function. A general improvement in conditions was observed after an 11-day program of treatment comprising a regular...