We attempted to measure the benefits of a communitywide hemoglobinopathy screening program by reviewing the numbers of newborns detected to have a hemoglobinopathy, the level of utilization of prenatal diagnostic services, and the number of hemoglobinopathies diagnosed prenatally. We measured the effect of our program on 14,051 infants born over a five year period and their families. Results: T...

background: thalassemia is a series of hemoglobinopathies in which the production of perfect hemoglobin is completely or partially suppressed. using injectable iron chelators have been dominating treatment for the iron overload caused by recurrent blood transfusions in thalassemic patients, however, a new oral iron chelating drug (exjade) have been recently introduced and might be cost effectiv...

BACKGROUND The high frequency of hemoglobinopathies in Brazil constitutes a public health problem and thus educational and preventive measures are necessary to reduce the incidence. Genetic guidance, a modality of genetic counseling, and family screening are measures that can assist in reproductive decisions and mitigate clinical, psychological and social problems of families with these disorde...

BACKGROUND Brazil has a multiethnic population with a high diversity of hemoglobinopathies. While screenings for beta-globin mutations are far more common, alterations affecting alpha-globin genes are usually more silent and less well known. The aim of this study was to describe the results of a screening program for alpha-globin gene mutations in a representative sample of the Southeastern Bra...

The only well-established curative therapy for patients with hemoglobinopathies is allogeneic hematopoietic stem cell transplantation (HSCT), which, in the last 20 years, has been mainly performed from an HLA-matched, related donor, using bone marrow as source of hematopoietic progenitors. More recent studies indicate that HSCT from unrelated donors may offer results comparable to those obtaine...

of fructosamine values between these two populations are not significantly different. These results imply two different distributions for measurements of Hb A1 but the same gaussian (anamorphosis) distribution for measurements of fructosamine. H,qerglycemk patients. Statistical analysis of the data (Mann-Whitney test) shows a significant difference of fructosamine averages between normal subjec...

OBJECTIVES To analyze the results of hemoglobin electrophoresis (HE) in the routine laboratory of a tertiary hospital in Kuwait and to review the common types of hemoglobinopathies prevalent in the country. METHODS This was a prospective study of HE performed on 2,386 samples in Mubarak Al-Kabeer Hospital, which serves more than 30% of the population of Kuwait, from June 1997 to May 1998. R...