Hemoglobin H is of particular interest since it consists only of j3 chains (1). This abnormal hemoglobin, therefore, presents a unique opportunity for investigating the imluence of a-j3 chain interactions on some of the structural and functional properties of hemoglobin. The hemoglobin H used for these studies was obtained from two patients. The first patient, L. G., was a 25-year-old woman of ...

BACKGROUND Normally, one pair of each of the two alpha-globin genes, alpha1 and alpha2, resides on each copy of chromosome 16. In hemoglobin H disease, three of these four alpha-globin genes are affected by a deletion, a mutation, or both. We studied the alpha1-globin gene abnormalities and the clinical and hematologic features of Chinese patients with hemoglobin H disease in Hong Kong. METHO...

Certain aspects of the metabolism of centrifuged young and old erythrocytes in hemoglobin H disease have been examined and compared with similar studies of beta thalassemia and normal cells. Glycolysis, hexose monophosphate shunt activity (HMPS), potassium flux, and glutathione (GSH) content were measured. The distributions of hemoglobins H and F, as well as the activities of erythrocyte glucos...

BACKGROUND/OBJECTIVES Awareness of hemoglobin level variability in dialysis patients is increasing, as is interest in its potential implications. In this retrospective, national study of associations between the degree of hemoglobin level variability in the first 6 mo of 2004 and subsequent mortality rates in the following 6 mo, 159,720 hemodialysis patients receiving epoetin therapy were studi...

I N 1955 RIGAS ET AL.1 and Gouttas et al.2 independently reported the discovery of a new hemoglobin characterized electrophoretically at pH 8.6 by a more rapid anodal mobility than that of normal adult hemoglobin. This hemoglobin has subsequently been identified by the letter “H.” More recently, “fast” hemoglobins other than “H” have been described. These include hemoglobins J,3 J,4-1#{176} K,5...

We report the case of an Italian infant girl hand, in the Askenazy carriers of Hb Hafrom Polesine (Po delta region in northern sharon, Hb Hasharon is probably linked to Italy) who was heterozygous for Hb Haa normal a gene. In comparing Hb Hasharon and a-thalassemia, did not synthesharon’s behavior with that of other a size any normal HbA, and had 3% HbH on variants, particularly HbG Philadelphi...

OBJECTIVES Published data indicate that Alpha thalassemia trait is prevalent in 45% of population of Sultanate of Oman. Recent unpublished data suggest that this prevalence is higher than 45%. Yet clinical suspicion or investigations into α-thalassemias are lacking. Moreover, Hemoglobin H disease is considered rare in Oman. We decided, therefore to look for Hemoglobin H disease and characterize...