A number of recent reports indicate the existence of more than one type of helper T cell (I-6). A previous publication from our laboratory (3) demonstrated two types of carrier-specific helper T cells that independently and synergistically exert helper effects on the hapten-specific antibody response. One type (Thl) 1 is a more conventional helper T cell that helps hapten-specific B cells only ...

Mucosal and parenteral immunizations elicit qualitatively distinct immune responses, and there is evidence that mucosal immunization can skew the balance of T helper 1 and T helper 2 responses. However, a clear picture of the effect of the route of infection on the balance of the T helper responses has not yet emerged. Our laboratory previously demonstrated that oral reovirus infection elicits ...

The murine model of leishmaniosis is a prototypic example for the critical role played by T helper cells in immunity to pathogens. Cytokines, such as interleukin-12 and interleukin-4, are the major regulatory factors for differentiation of naive T helper cells into T helper 1 and T helper 2 cells, respectively. T helper 1 cells, which are cellular immune mechanisms involving gamma interferon pr...

This survey covers the general idea behind helper threads and the major ways in which they are implemented. The first section covers parallel helper threads and the issues crucial to their role in improving performance. The following sections cover the implementations of parallel helper threads, focusing on SMT processor based implementations and adapted superscalar processor based implementati...

Monoclonal antisera against helper (serum OKT4) and suppressor (serum OKT8) T cells were employed in a complement-dependent lymphocytotoxicity reaction to isolate helper and suppressor T cells from peripheral blood mononuclear cells. When prepared by this method, helper and suppressor T cells had a purity of 67.8 percent and 78.8 percent, respectively. Approximately 56 percent of viable suppres...

Sindbis vectors have shown remarkable antitumor efficacy and tumor-targeting capacity in animal models and hold promise for cancer therapy. Different packaging systems are used to produce propagation-incompetent Sindbis vectors. However, the vectors produced using either DH-BB single helper RNA or split helper RNA can spread in permissive cell cultures. We investigated the mechanisms of vector ...

Data prefetching via helper threading has been extensively investigated on Simultaneous MultiThreading (SMT) or Virtual Multi-Threading (VMT) architectures. Although reportedly large cache latency can be hidden by helper threads at runtime, most techniques rely on hardware support to reduce context switch overhead between the main thread and helper thread as well as rely on static profile feedb...