Imbalanced protein load within cells is a critical aspect for most diseases of aging. In particular, the accumulation of proteins into neurotoxic aggregates is a common thread for a host of neurodegenerative diseases. Our previous work demonstrated that age-related changes to the cellular chaperone repertoire contributes to abnormal buildup of the microtubule-associated protein tau that accumul...

a 2-year period a tenacious film formed. Daily free passage of sponge rubber balls through the tubing only removed the loose surface biofouling layer and was inadequate as a countermeasure in both titanium and aluminum alloy tubes. Chlorination at 0.05, 0.07, and 0.10 mg liter-' for 1 h day'1 lowered biofouling rates. Only at 0.10 mg liter-' was chlorine adequate over a 1-year period to keep fi...

The recently emerged chytrid fungus Batrachochytrium salamandrivorans currently causes amphibian population declines. We hypothesized that temperature dictates infection dynamics of B. salamandrivorans, and that therefore heat treatment may be applied to clear animals from infection. We examined the impact of environmental temperature on B. salamandrivorans infection and disease dynamics in fir...

On airport runways, blue light fixtures denote taxiways between the runway and the airport terminal. Blue optics transmit mostly short-wavelength radiation, which makes traditional incandescent lamps a poor choice of light source; the resulting fixture efficiency could be less than one percent. LEDs are replacing incandescent lamps in this application. But unlike incandescent sources, LEDs do n...

The use of abrasive waterjets for cutting into munitions of varying types as part of the decommissioning process is becoming more common. The performance of one such system, operated at 700 bar is discussed, from the aspect of cutting performance in sectioning 40 mm shells. The amount of sparking generated, and the thermal buildup of heat on the inner wall of the munition is discussed, as part ...

Background: The accuracy and the reproducibility of radiotherapy can be provided by using immobilization devices such as thermoplastic masks. In head and neck cancer radiotherapy, the patients are mostly immobilized by using thermoplastic masks. In this study, the effect of the thermoplastic mask to the surface and buildup region doses was investigated by using Markus parallel plate ion chamber...

Abstract Measurements of ultrahigh-fidelity absorption spectra can help validate quantum theory, engineer ultracold chemistry, and remotely sense atmospheres. Recent achievements in cavity-enhanced spectroscopy using either frequency-based dispersion or time-based approaches have set new records for accuracy with uncertainties at the sub-per-mil level. However, laser scanning susceptibility to ...

human body consists of some tissues among which bone is one of the important living and growing tissue . in this research, energy absorption buildup factor (eabf) values of 27 types of bone have been computed for photon energy 0.03 to 1.5 mev up to 40 mean free path (40mfp) penetration depths. the inner bone tissue, spongiosa and male sternum had the largest values of eabf in low photon energie...

Neutron dose-equivalent buildup factors were calculated for point isotropic neutron sources irradiating infinite slablike shields of lead, iron and water using the MCNP code. The factors are presented for some source neutron energies in the range from 0.025 eV to 14 MeV, and for shield thicknesses from 0.5 to 10 mfp. Since the MCNP code considers all kinds of neutron interactions with matter, a...

Stream segregation is the process by which the auditory system disentangles the mixture of sound inputs into discrete sources that cohere across time. The length of time required for this to occur is termed the "buildup" period. In the current study, we used the buildup period as an index of how quickly sounds are segregated into constituent parts. Specifically, we tested the hypothesis that st...