Current cellular models of ischemic preconditioning (IPC) rely on inducing preconditioning in vitro and may not accurately represent complex pathways triggered by IPC in the intact heart. Here, we show that it is possible to precondition the intact heart and to subsequently isolate individual ventricular myocytes that retain the protection triggered by IPC. Myocytes isolated from Langendorff-pe...

BACKGROUND Neurodevelopmental delays in motor skills and white matter (WM) injury have been documented in congenital heart disease and after pediatric cardiac surgery. The lack of a suitable animal model has hampered our understanding of the cellular mechanisms underlying WM injury in these patients. Our aim is to identify an optimal surgical strategy for WM protection to reduce neurological in...

The path-segment-protecting p-cycles (“flow p-cycles” for short) have capacity efficiency near that of the Shared Backup Path-Protection (SBPP) scheme currently favoured for optical networking. In this paper a significant extension to the method of p-cycle is introduced for network protection. The Flow p-cycle is use to protect path segments of adjacent workingflow, directly straddle the p-cycl...

BACKGROUND Ischemic preconditioning is a powerful mechanism in reducing infarct size of the heart. Protection can be performed either by an ischemic stimulus of the heart itself or by ischemia of an organ distant to the heart. To address the question whether this remote preconditioning is transduced by neuronal or humoral factors an in situ model of infrarenal occlusion of the aorta (IOA) in th...

introduction: rheumatic heart disease still remains one of the leading causes of congestive heart failure and death owing to valvular pathologies, in developing countries. valve replacement still remains the treatment of choice in such patients.the aim of this study wasto analyze the postoperative outcome of  double valve replacement (mitral and aortic ) in patients of rheumatic heart disease. ...