This study examined the effects of arginine supplement of fluid resuscitation from burn injury on cardiac contractile performance and bacterial translocation after a third-degree burn comprising 43% of the total body surface area in adult rats. Before burn injury, rats were instrumented to measure blood pressure; after burn (or sham injury), paired groups of sham-burned and burned rats were giv...

BACKGROUND Patients with major burns accompanied with airway edema need more attention for airway management. Although the Pentax-AWS has an advantage in managing endotracheal intubation more easily, its usefulness cannot be assured if it does not maintain hemodynamic stability in burn patients. The aim of this study was to compare cardiovascular responses and general efficacy of the Pentax-AWS...

Mechanisms of burn-related cardiac dysfunction may involve defects in mitochondria. This study determined 1) whether burn injury alters myocardial mitochondrial integrity and function; and 2) whether an antioxidant vitamin therapy prevented changes in cardiac mitochondrial function after burn. Sprague-Dawley rats were given a 3 degrees burn over 40% total body surface area and fluid resuscitate...

Carlson, Deborah L., D. Jean White, David L. Maass, Robin C. Nguyen, Brett Giroir, and Jureta W. Horton. I B overexpression in cardiomyocytes prevents NFB translocation and provides cardioprotection in trauma. Am J Physiol Heart Circ Physiol 284: H804–H814, 2003; 10.1152/ ajpheart.00394.2001.—This study examined the effects of either I B overexpression (transgenic mice) or N-acetylleucinyl-leuc...

We have recently demonstrated that macrophage migration inhibitory factor (MIF) is a myocardial depressant protein and that MIF mediates late, prolonged cardiac dysfunction after endotoxin challenge in mice. Because many factors, including endotoxin, have been implicated in the pathogenesis of cardiac dysfunction after burn injury, we tested the hypothesis that MIF might also be the mediator of...

Burn injury probably first occurred during the prehistoric era, soon after human beings were able to make fire for cooking and keeping warm during cold seasons. It had been stated in the old medical writings that the death of a burn victim was due to an assault to the heart by flame toxin. Though different kinds of salves had been used for the treatment, the efforts were usually of no avail and...

Gut-derived factors in intestinal lymph have been shown to trigger myocardial contractile dysfunction. However, the underlying cellular mechanisms remain unclear. We examined the effects of physiologically relevant concentrations of mesenteric lymph collected from rats with 40% burn injury (burn lymph) on excitation-contraction coupling in rat ventricular myocytes. Burn lymph (0.1-5%), but not ...

health problems and sudden death is common among athletes. the main purpose of this study was, investigating number of risk factors that related to heart disease and injuring duration of exercise for champions. the samples were comprised of 50 sport teachers and 63 competitive athletes that were selected from candidates being ready fornational championship. burn out, anxiety, hostility and ange...