Radiotherapy plays an important role in the treatment of most solid tumors including head and neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recurrence distant metastases. Despite significant progress research radioresistance, its prediction overcoming strategies remain challenging. This review describes potential biomarkers correlated radioresistance complex sig...

Carcinoma of the head and neck represents 3.5% of all cancers, and the vast majority of these tumors are squamous cell carcinoma (HNSCC). With a stable overall survival rate of 50% among all stages, there is continued interested in developing measures for early detection and disease aggressiveness. Circulating tumor cells (CTCs) have been identified as a potential marker for early metastatic di...

background: fanconi anemia (fa) is an autosomal recessive disorder characterized by congenital malformations, bone marrow failure, development of squamous cell carcinoma (scc), and other cancers. human papillomavirus (hpv) in the oral cavity or oropharynx has been associated with an increased risk of laryngeal papillomatosis, invasive squamous cell carcinoma of the head and neck (hnscc) and cer...

Introduction: HER2/neu, a member of the epidermal growth factor receptor family, has been shown to be over-expressed in some tumors. The purpose of this study was to determine the salivary levels and tissue expression of HER2/neu in patients with head and neck squamous cell carcinoma (HNSCC) and their correlation with clinicopathologic parameters.   Materials and Methods: Enzyme-linked immu...

Head and neck cancer was the eighth leading cause of cancer death worldwide in 2000. Although the incidence of head and neck squamous cell carcinoma (HNSCC) in the United States is relatively low, survival is poor and has not improved for several decades. While tobacco and alcohol are the primary risk factors for HNSCC development, epidemiological studies report a strong association with human ...

introduction: squamous cell carcinoma (scc) is the most common head and neck malignancy. smoking, alcohol consumption, viral infections, exposure, oral hygiene, and dietary, genetic, and occupational factors are the most important etiologic factors. the aim of this study was determining the incidence of etiologic factors in head and neck scc.  materials and methods: this is a cross-sectional su...

HNSCC: head and neck SCC SCC: squamous cell carcinoma SSS: secondary SCC of the skin INTRODUCTION Metastatic squamous cell carcinoma (SCC) to the skin, also known as secondary SCC of the skin (SSS), is a rare entity that represents advanced disease and carries a poor prognosis. The most commonly reported primary sources for metastatic SCC to the skin are head and neck cancers of the larynx, oro...

Cancer cell lines are the basic material for various lines of cancer research. Diverse cancer cell lines derived from tissues of various head and neck regions are needed for biological research on head and neck cancer. However, cell lines derived from cancer of the head and neck are not common. Recently, we established and characterized a novel human squamous carcinoma cell line, CNUH-HNSCC-1. ...

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide associated with high mortality. The main reasons for treatment failure are a low rate of early diagnosis, relapse rates, distant metastasis poor outcomes. These largely due to lack diagnostic, prognostic, predictive biomarkers in HNSCC. DNA methylation has been demonstrated play an important role pathogenesi...

Introduction: The presence of HER-2 has been shown to be a prognostic factor in many kinds of cancers, but its role in head and neck squamous cell carcinoma (HNSCC) is not still defined. The purpose of the current study is to investigate the role of HER-2 in HNSCC and its correlation with various clinicopathologic parameters.   Materials and Methods: Peripheral blood samples were obtained ...