BACKGROUND Psoriasis is a chronic immune-mediated inflammatory disease, and a mixed Th1/Th17 cytokine environment plays a critical role in the pathogenesis of psoriasis. Dermal fibroblasts secrete certain cytokines such as IL-6, IL-8, and CXCL-1, contributing to the hyperproliferative state of the epidermis in psoriatic skin. Ultraviolet B (UVB) phototherapy is one of the most commonly used tre...

Oxidative stress induced by reactive oxygen species (ROS) is the major cause of degenerative disorders including aging and disease. In this study, we investigated whether Cordyceps militaris extract (CME) has in vitro protective effects on hydrogen peroxide-induced oxidative stress in human dermal fibroblasts (HDFs). Our results showed that the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scave...

Emerging evidences highlight the implication of microRNAs as a posttranscriptional regulator in aging. Several senescence-associated microRNAs (SA-miRNAs) are found to be differentially expressed during cellular senescence. However, the role of dietary compounds on SA-miRNAs remains elusive. This study aimed to elucidate the modulatory role of tocotrienol-rich fraction (TRF) on SA-miRNAs (miR-2...

In this work, we show that repeated stresses with UVB (290-320 nm) induce stress-induced premature senescence (SIPS) of skin human diploid fibroblasts (HDFs). HDFs at early cumulative population doublings were exposed three or five times to increasing subcytotoxic doses of UVB with one stress per day. After 2 days of recovery, several biomarkers of replicative senescence were established. First...

Hadoop is an open-source data processing framework that includes a scalable, faulttolerant distributed file system, HDFS. Although HDFS was designed to work in conjunction with Hadoop’s job scheduler, we have re-purposed it to serve as a grid storage element by adding GridFTP and SRM servers. We have tested the system thoroughly in order to understand its scalability and fault tolerance. The tu...

We present a study of photometric properties of the galaxies in the Hubble Deep Field South (HDFS) based on the released WFPC2 images obtained with the Hubble Space Telescope (HST). We have classified about 340 galaxies with I < 26 mag in the HDFS as well as about 400 galaxies in the Hubble Deep Field North (HDFN) using the visual classification supplemented by inspection of the surface brightn...

Distributed file system for the storage of massive files have obvious advantages compared with the conventional file system. For instance, Hadoop Distributed File System (HDFS) implemented with commodity hardware has the advantages of low cost, high fault tolerance, scalability, etc. However, HDFS has the potential safety hazard due to the unencrypted data stored in Datanode, which may cause da...

We present a study of photometric properties of the galaxies in the Hubble Deep Field South (HDFS) based on the released WFPC2 images obtained with the Hubble Space Telescope (HST). We have classified about 340 galaxies with I < 26 mag in the HDFS as well as about 400 galaxies in the Hubble Deep Field North (HDFN) using the visual classification supplemented by inspection of the surface brightn...

Recent improvements in both the performance and scalability of shared-nothing, transactional, in-memory NewSQL databases have reopened the research question of whether distributed metadata for hierarchical file systems can be managed using commodity databases. In this paper, we introduce HopsFS, a next generation distribution of the Hadoop Distributed File System (HDFS) that replaces HDFS’ sing...