The purpose of this study was to determine the prevalence and distribution of HCV genotypes among voluntary blood donors in northern Thailand. From 1998 to 2000, 167 serum samples which tested positive for anti-HCV antibodies in the screening of voluntary blood donors from 5 provinces in northern Thailand were selected for genotyping. Viral RNA was extracted from the sera. The core-E1 region of...

The genotypic distribution of hepatitis C virus (HCV) isolated from blood donors from four major regions of Thailand was studied by reverse hybridization assays. PCR-amplified products from the 5' noncoding and core regions of the viral genome were hybridized to genotype- and subtype-specific probes which were immobilized on the nitrocellulose membrane. Of 332 anti-HCV-positive plasma samples s...

background and objectives: hepatitis c virus (hcv) infection is a worldwide concern and it is the major cause of liver disease. several genotypes of the hcv have been reported from different regions of the world. the determination of the hcv genotypes is important for the prediction of response to antiviral treatment and clinical outcomes. so, hcv genotyping in each region is of great importanc...

results the highest prevalent genotype was genotype 4a, which was found in 57 patients (92%) followed by 2 isolates (3%) with genotype 4o, 2 strains (3%) with genotype 1g and one isolate (2%) with genotype 4n. conclusions this molecular epidemiology study revealed high prevalence of hcv genotype 4, subtype 4a among egyptian patients residing in sharkia governorate, egypt. patients and methods t...

AbstractObjectives Porto Alegre, in south Brazil, has one of the highest hepatitis C virus (HCV) infection rates country (84.4 cases/100 000 2018). Prenatal screening HCV, however, not been routinely offered. Methods A longitudinal study pregnant women with HCV and their infants was conducted between January 2014 December 2018. Screening for antibodies offered to all ...

background: hepatitis c is a disease with significant global impact. the distribution of hepatitis c virus (hcv) genotypes in mashhad (the northeast and the biggest city after the capital of iran) is unknown. the purpose of this study was to determine the prevalence of hcv genotypes among hcv seropositive patients, and to study the relationship between types, virologic and demographic features ...

OBJECTIVE To elucidate the importance of hepatitis C Virus (HCV) genotype in HIV disease progression. DESIGN This study was conducted among 126 HIV/HCV co-infected drug users with a known interval of HIV seroconversion whose HCV genotype was known early in HIV infection. Both clinical progression (to AIDS) and immunological progression (to a CD4+ T-cell count of 200 x 10(6) cells/l) by HCV ge...

Results: ALT level was normal in 50 patients (68.5%), intermittently high in 18 patients (24.8%) and persistently high in 5 patients (6.8%). HCV RNA (57, 5 %) was positive in 42 of 73 patients. HCV genotype was determined in 29 patients. HCV genotype 1a was detected in three cases and HCV genotype 1b was detected in 26 patients. There was no difference between HCV RNA positive patients and HCV ...

Abstract Background and Aims: The Hepatitis C Virus (HCV) is essentially hepatotropic but virus compartment has also been found in other important extra hepatic sites. Detection of HCV RNA in extra hepatic reservoirs such as peripheral blood mononuclear cells (PBMCs) is important for determining of disease progression and effective treatment. The present study aimed to determine of differe...

conclusions in conclusion, the prevalence of hcv genotype 1 was 51.7%, which was lower than the rates reported in other studies in turkey, while the prevalence of hcv genotype 3 was 46%, which was remarkably higher than the reported turkish data. in addition, the prevalence rate for genotype 3 reported in the present study is the highest that has ever been reported in the literature. results th...