I most Asian countries, with a general carrier rate of 5%–35%, hepatitis B virus (HBV) infection is hyperendemic (1). HBV is a member of Hepadnaviridae, a family of enveloped hepatotropic DNA viruses. It has a circular, partially doublestranded DNA of 3200 nt (2). This virus can cause severe liver disease with eventual progression to cirrhosis and primary hepatocellular carcinoma (HCC) (3). HBV...

INTRODUCTION Mutation of the HBV precore gene prevents the production of HBeAg, which is an important target for immune responses. Distribution of this mutation varies along with frequency of HBV genotypes in accordance with geographic and ethnic variations. The general objective of this study was to evaluate the prevalence and characteristics of precore mutation in Iran and its correlation wit...

Hepatitis B (HBV) and C (HCV) virus infection are the most important infections transmitted by the parenteral route in hemodialysis patients. This study is the first report of prevalence of viral hepatitis and hepatitis C virus genotypes in southwest Iran among hemodialysis patients. A cross-sectional study was carried out among 214 hemodialysis patients of the Central hemodialysis unit, from M...

background and aims: hepatitis b virus (hbv) infects the liver and causes acute and chronic hepatitis, hepatocellular carcinoma and cirrhosis. hbv has been divided to eight genotypes (a–h) and subgenotypes of a, b, c and f. for the first time, we determined hbv genotypes in infected samples by inno-lipa method in yazd, central province of iran. materials and methods: this study was performed on...

BACKGROUND The association between mutations in the hepatitis B surface antigen (HBsAg) gene and the occurrence of occult HBV (OBI) in patients has not been studied adequately to determine if the two are correlated. The current study was aimed to investigate HBsAg mutations, the genotype of HBV and co-infection with HCV in OBI in the central part of Iran to determine any possible associations. ...

conclusions in conclusion, the prevalence of hbv infection was low in the south of iran, but genotype d represented the major hbv genotype in this population. among the variables, age, duration of hd, history of blood transfusion, and using shared hd devices influenced the prevalence of hbv among hd patients. results both kinds of assay determined that nine (5.88%) patients were hbv positive (h...

OBJECTIVE To identify the distribution pattern of Hepatitis B Virus (HBV) genotype in a group of patients and to study its phylogenetic divergence. STUDY DESIGN An observational study. PLACE AND DURATION OF STUDY The clinics of Gastroenterology Unit, Ziauddin University, from January to December 2006. METHODOLOGY Two hundred and one HBV infected patients were genotyped for this study. All...

Hepatitis B virus (HBV) infection is the most common cause of end stage liver disease in Iran and in Golestan province. Large-scale population-based prospective cohort studies with long term follow-up are the method of choice to accurately understand the natural course of HBV infection. To date, several studies of HBV epidemiology, natural history, progression to cirrhosis and association with ...

methods and materials: hepatitis b virus dna was detected by conventional pcr in some of the serum samples obtained from hbsag-positive chronic hepatitis b (chb) patients who were referred to health centers of shahrekord for routine monitoring of the disease. subsequently, using real-time pcr, the dna samples were used for genotyping and analysis of resistance to lamivudine. results: the dna wa...