Reduced endothelium-dependent vasodilator responses with increased synthesis of ET-1 (endothelin-1) are characteristics of endothelial dysfunction in heart failure and are predictive of mortality. Identification of treatments that correct these abnormalities may have particular benefit for patients who become refractory to current regimens. Hawthorn preparations have a long history in the treat...

The zebrafish is becoming an increasingly popular model system for both automated drug discovery and investigating hypercholesterolemia. Here we combine these aspects and for the first time develop an automated high-content confocal assay for treatments of hypercholesterolemia. We also create two algorithms for automated analysis of cardiodynamic data acquired by high-speed confocal microscopy....

STUDY OBJECTIVE To determine the effects of hawthorn (Crataegus oxycantha) on left ventricular remodeling and function in pressure overload-induced heart failure in an animal model. DESIGN Randomized, parallel, dose-ranging animal study. SETTING University research facility. ANIMALS Seventy-four male Sprague-Dawley rats; 44 were included in the final analysis. INTERVENTION Rats underwen...

Extracts of hawthorn (Crateagus sp.) have been indicated in the treatment of cardiovascular diseases, however, tablets produced from dry extract due to a multiple of factors such as inconsistent botanical ingredients, moisture content and hygroscopicity turn to be hard with prolong disintegration. Dissolution test is increasingly being employed for the assessment of solid herbal medicinal dosag...

M.M. DAvaS,*t L.J. BERG,t..A.Y. Ln~,*t B. FAZEKAS DE ST. GROTH,t B. DEVAUX,*t C.G. SAGERSTROM,t P.J. BJORKMAN,r AND J .F . ELLIOTTtw *Howard Hughes Medical Institute and tThe Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5428; J~Biology Division, The California Institute of Technology, Pasadena, California 95205; w DNAX Research In...

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn ex...

The aim of this work was to determine the content of total polyphenols, total flavonoids, total monomeric anthocyanins, total proanthocyanidins, and antioxidant activity of Crataegus monogyna L. fruit in water, hydroalcohol and alcohol extracts. Phenolic content and antioxidant assay of the different fruit extracts was determined using spectrophotometric methods. Obtained results indicated that...

Hawthorn (Crataegus spp.) is an important pome with a long history as a fruit, an ornamental, and a source of medicine. Fruits of hawthorn are marked by hard stony endocarps, but a hawthorn germplasm with soft and thin endocarp was found in Liaoning province of China. To elucidate the molecular mechanism underlying the soft endocarp of hawthorn, we conducted a de novo assembly of the fruit tran...

Fructus crataegi (hawthorn) is the common name of all plant species in the genus Crataegus of the Rosaceae family. In the present study, three monomers of (+)-catechin (C), (-)-epicatechin gallate (ECg) and (-)-epigallocatechin (EGC) were isolated from the hawthorn under the guide of antibacterial sensitization activity. The bioactivity of the composite fraction in enhancing the antibacterial ...