Harmaline and harmine occur naturally in plants and are distributed endogenously in human and animal tissues. The two β-carboline alkaloids possess potential for treating Alzheimer's disease, Parkinson's disease, depression and other central nervous system diseases. However, studies have showed that the two compounds have similar structures but with quite different bioavailability. The aim of t...

PURPOSE Harmaline is one member of a class of tremorgenic harmala alkaloids that have been implicated in neuroprotective effects and neurodegenerative disorders. It has been reported to interact with several neurotransmitter receptors as well as ion exchangers and voltage-sensitive channels. One site of harmaline action in the brain is the inferior olive (IO). Either local or systemic harmaline...

Plant and plant products are the major source for the discovery of new drugs. Alangium salviifolium utilized in traditional medicine has resourceful medicinal properties.The aim of present study was to evaluate the biological activity of alkaloid β Carboline harmaline of Alangium salviifolium in cell growth activity inhibition. The potentiality of the alkaloid compound in inhibition of MTHFR wi...

introduction: excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. we hypothesized that antiglutamatergic agents would suppress harmaline tremor. from this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. material and methods: four groups of wistar rats weighing 80–100 g were injected with harmaline...

Introduction: The plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-HT) system on cognitive and non-cognitive behaviors. Thus, the purpose of this study is to assess the effects of hippocampal 5-HT4 receptor on memory acquisition deficit induced by harmaline.  Methods: Harmaline was injected peritoneally, while 5-HT4 receptor ago...

The genetically dystonic rat (dt) displays a complex movement disorder in the absence of morphological defects in the nervous system. This mutant is also insensitive to the tremorogenic effects of harmaline. Because harmaline is known to act on the cells of the inferior olive to induce activity at the tremor frequency in the olivocerebellobulbar pathway, this pathway has been investigated as a ...

Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulat...

Introduction: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of current study was to investigate the effects of riluzole on harmaline-induced tremor in rat. Material and Methods: Four groups of Wistar rats weighing 80–100 g were injected with harmaline...

the plethora of studies indicated that there is a cross talk relationship between harmaline and serotonergic (5-ht) system on cognitive and non-cognitive behaviors. thus, the purpose of this study is assessment the effects of ca1 5-ht4 receptor on memory acquisition deficit induced by harmaline. harmaline was injected peritoneally, while 5-ht4 receptor agonist (rs67333) and antagonist (rs23597-...