PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested. The most recent study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region in a Caucasian population. In this study, a family-...

Suspicion of failure in the effectiveness artemisinin-based combination therapies (currently first-line treatment malaria, worldwide) is leading to unofficial use alternative antimalarials, including chloroquine and sulfadoxine/pyrimethamine, across northern Nigeria. To facilitate evidence-based resistance management, antimalarial mutations were investigated Plasmodium falciparum multidrug resi...

medullary thyroid carcinoma (mtc) occurs in both sporadic (75%) and hereditary (25%) forms. the missense mutations of the rearranged during transfection (ret) proto-oncogene in mtc development have been well demonstrated. the aim of this study was to investigate frequency of g691s/s904s haplotype in mtc patients and their relatives.in this research 293 participants were studied, including 181 p...

objective: plasmodium falciparum chloroquine resistance is a major problem in malaria endemic areas. single nucleotide polymorphisms in pfcrt and pfmdr1 genes are known to be associated with chloroquine resistance in some parts of the world. the major goal of the present study was to detect the five single nucleotide polymorphisms in pfmdr1 gene and one single nucleotide polymorphisms in pfcrt ...

background: different studies have demonstrated that a small proportion of healthy individuals receiving the hepatitis b (hb) vaccine do not produce protective levels of anti-hb antibody, a phenomenon which could be linked to certain human leukocyte an-tigen (hla) class-ii alleles or haplotypes. objectives: the present study was under-taken to determine the frequency of hla class-ii alleles in ...