We introduce an algorithm for MinA extraction in EL based on bidirectional reachability. We obtain a significant reduction in the size of modules extracted at almost no additional cost to that of extracting standard reachability-based modules. Bidirectional modules are related to nested locality modules, but are aimed specifically at MinA extraction and are generally smaller. For acyclic EL TBo...

The ability of oximes to reactivate organophosphorus nerve agent-inhibited acetylcholinesterase (AChE) activity is critical for protection against chemical warfare nerve agent intoxication. We have studied the capability of the tertiary oximes monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), in comparison with the quaternary oximes 2-PAM, HLo7 and MMB-4 to reactivate AChE inhibited by s...

The current treatment regimen for organophosphorus nerve agent intoxication depends on the ability of oximes to rapidly reactivate nerve agent-inhibited acetylcholinesterase (AChE) activity. We have studied the capability of the tertiary oximes monoisonitrosoacetone (MINA) and diacetylmonoxime (DAM), in comparison with the quaternary oximes 2-PAM, HLö7 and MMB-4, to reactivate AChE inhibited by...

BACKGROUND This study analyzes the characteristics of donor and recipient tissue preparation between the Hessburg-Barron and Hanna punch and trephine systems by using elliptical curve fitting models, light microscopy, and anterior segment optical coherence tomography (AS-OCT). METHODS Eight millimeter Hessburg-Barron and Hanna vacuum trephines and punches were used on six cadaver globes and s...

Current oxime therapies do not readily cross the blood-brain barrier to reactivate organophosphorus nerve agent-inhibited cholinesterase (ChE) within the CNS. We investigated the ability of monoisonitrosoacetone (MINA), a tertiary oxime, to reactivate ChE inhibited by the nerve agent sarin (GB), cyclosarin (GF), or VX, in peripheral tissues and brain of guinea pigs and determined whether reacti...

M ina Bissell has never been afraid to challenge conventional wisdom, whether on a woman's role in the laboratory or on how a cell's context determines its function. Bissell came to the US from Iran to study chemistry at Bryn Mawr and Radcliffe Colleges, before pursuing a PhD in bacteriology at Harvard Medical School. She moved to California for her postdoc in virol-ogy, before joining the Lawr...

1 This thesis is devoted to the memory of my grandmother Mina.