T he events narrated by Shakespeare in his tragedy Hamlet 1 are the following: King Hamlet of Denmark dies suddenly and his brother Claudius a few weeks later marries the widow, his sister-in-law, Queen Gertrude; according to the official explanation, a snakebite was the cause of his death. The ghost of the king appears before his son, Prince Hamlet, and tells him that his own brother, now his ...

The p38 mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in stress-induced cell-fate decisions by orchestrating responses that go from cell-cycle arrest to apoptosis. We have identified a new p38 MAPK-regulated protein that we named p18(Hamlet), which becomes stabilized and accumulates in response to certain genotoxic stresses such as UV or cisplatin treatment. ...

Focusing on the cultural significations and artistic capacities of naqqali, this article examines the comparative workings of this Iranian popular genre in Hossein Jamali’s Hamlet: The Retribution Affair. Jamali’s adaptation is worth considering since it narrates the whole events and characters of Shakespeare’s Hamlet, a classic text of English literature, through naqqali, a classic Persian gen...

parody as a salient device in postmodern literature is extensively applied by tom stoppard in his plays. having different layers of parody, stoppard’s “rosencrantz and guildenstern are dead”, “the real inspector hound”, and “dogg’s hamlet, cahoot’s macbeth” exhibit his parodic application of other writers’ plots. the analytical-qualitative scrutiny of the plot lines of these plays not only corr...

Long-chain fatty acids are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks, and signaling intermediates. Here we describe how the association of long-chain fatty acids to a partially unfolded, extracellular protein can alter the presentation to target cells and cellular effects. HAMLET (hu...

HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a protein-lipid complex from human milk with both tumoricidal and bactericidal activities. HAMLET exerts a rather specific bactericidal activity against some respiratory pathogens, with highest activity against Streptococcus pneumoniae, but lacks activity against most other bacterial pathogens, including Staphylococci. Still, ion tr...

HAMLET and ELOA are complexes consisting of oleic acid and two homologous, yet functionally different, proteins with cytotoxic activities against mammalian cells, with HAMLET showing higher tumor cells specificity, possibly due to the difference in propensity for oleic acid binding, as HAMLET binds 5-8 oleic acid molecules per protein molecule and ELOA binds 11-48 oleic acids. HAMLET has been s...

Efficient label acquisition processes are key to obtaining robust classifiers. However, data labeling is often challenging and subject to high levels of label noise. This can arise even when classification targets are well defined, if instances to be labeled are more difficult than the prototypes used to define the class, leading to disagreements among the expert community. Here, we enable effi...

HAMLET is a complex of α-lactalbumin (α-LA) with oleic acid (OA) that selectively kills tumor cells and Streptococcus pneumoniae. To assess the contribution of the proteinaceous component to cytotoxicity of HAMLET, OA complexes with proteins structurally and functionally distinct from α-LA were prepared. Similar to HAMLET, the OA complexes with bovine β-lactoglobulin (bLG) and pike parvalbumin ...

IN HIS FILM ADAPTATION of Hamlet (1996), Kenneth Branagh under­ scores the confessional themes present in the play by setting two scenes in a Roman Catholic confessional box. In the first scene, Po­ lonius interrogates Ophelia about her relationship with Ham­ let-an interaction that reinforces the common association of the confessional with an obsession over female sexuality. In the second scen...