Mixed malarial infections of Plasmodium falciparum and P. malariae are not uncommon but they may often be overlooked l?ecause there is a tendency for P. falcipa"fm .to predommate and the parasitaemia with P. malanae IS usually very low. Therapy of cases of mixed infections with P. falciparum !lnd P. malaria~, P. vivax or P. ovale should clearly ~e almed at P. falctparum as the potentially letha...

five per cent of the total cases of malaria in our country occur in children below 15 years of age(2). Of late, more and more cases appear to be resistant to chloroquine and also to other antimalarials(3). This is particularly so with Plasmodium falciparum malaria(4). In India, chloroquine resistant strains of P. falciparum were demonstrated in 19 states of the country in 1986(5). Halofantrine,...

the production of experimentally induced drug resistance in the laboratory provides valuable opportunities for investigators to study the nature and genetics of drug resistance mechanisms to a given agent, patterns of cross resistance and the mode of action of drugs. at the beginning the continuous drug exposure was chosen as a standard procedure to produce drug— resistant strains of p. falcipa...

The main objective of the present study was to evaluate the reduction in halofantrine (Hf) toxicity, an antimalarial drug frequently associated with QT interval prolongation in electrocardiogram, by its entrapment in poly-epsilon-caprolactone nanocapsules (NC). The acute lethal dose (LD(100)) of Hf.HCl experimentally observed was 200 mg/kg whereas the calculated LD(50) was 154 mg/kg. In contras...

The in vitro activities of dihydroartemisinin (the biologically active metabolite of artemisinin derivatives), chloroquine, monodesethylamodiaquine (the biologically active metabolite of amodiaquine), quinine, mefloquine, halofantrine, and pyrimethamine were assessed in 65 African isolates of Plasmodium falciparum from Yaounde, Cameroon using an isotopic microtest. The 50% inhibitory concentrat...

The spread of falciparum malaria resistant to chloroquine all over Southeast Asian continent has led to increasing use of alternative antimalarial drugs. Halofantrine has been shown to be effective against multidrug resistant Plasmodium falciparum. One hundred and twenty falciparum malaria cases were randomly assigned to one of three different halofantrine regimes. Group I (HA1) received 500 mg...

The oral route of drug administration is generally preferred because of its versatility, safety and relative patient comfort. Liposomes have received much attention for their usefulness in reducing toxicity and improving therapeutic effectiveness. Although liposomes are a most promising, broadly applicable, and highly researched novel delivery system, they suffer from serious stability problems...