Sigma-1 receptor antagonists promote antinociception in several models of pain, but the effects of sigma-1 agonists on nociception (particularly when the nociceptive system is primed) are not so well characterized; therefore we evaluated the effects of sigma-1 agonists on pain under different experimental conditions. The systemic administration of the selective sigma-1 agonists (+)-pentazocine ...

Student engagement is a key component of learning and teaching, resulting in plethora automated methods to measure it. Whereas most the literature explores student analysis using computer-based often lab, we focus on classroom instruction authentic environments. We collected audiovisual recordings secondary school classes over one half month period, acquired continuous labeling per (N=15) repea...

A previous study showed that cocaine self-administration induced dopamine-independent reinforcing effects of s agonists mediated by their selective actions at s1 receptors (s1Rs), which are intracellularly mobile chaperone proteins implicated in abuserelated effects of stimulants. The present study assessed whether the induction was specific to self-administration of cocaine. Rats were trained ...

Substrate based scar modification requires accurate detection and characterization of myocardial in sinus rhythm or using different wavefronts activation. Mapping during ventricular tachycardia can be performed only about 30% to 40% cases. We describe a challenging case VT with discrepancy the delineation between voltage mapping cardiac MRI role Decremental Evoked Potential as guide more focuss...

Alfred Christiaan SCHOUTEN werktuigkundig ingenieur geboren te Dordrecht, Nederland. Het onderzoek beschreven in dit proefschrift is mede mogelijk gemaakt door financiële on-dersteuning van de Nederlandse organisatie voor wetenschappelijk onderzoek, medische wetenschappen (NWO-MW, project nummer: 902-36-084). De pols manipulator beschreven in dit proefschrift is mede mogelijk gemaakt door een g...

Resting CD4+ T cells are a reservoir of latent HIV-1. Understanding the turnover of HIV DNA in these cells has implications for the development of eradication strategies. Most studies of viral latency focus on viral persistence under antiretroviral therapy (ART). We studied the turnover of SIV DNA resting CD4+ T cells during active infection in a cohort of 20 SIV-infected pigtail macaques. We c...

ISMIHAN BAIRAMOV, SAMUEL KOTZ and TOMASZ J. KOZUBOWSKI* Izmir University of Economics, Department of Mathematics, Sakarya Caddesi 156, 35330 Izmir, Turkey; Dept. of Engineering Management and Systems Engineering, School of Engineering and Applied Science, George Washington University, 1776=G Street, N.W., Washington, DC 20052, USA; University of Nevada, Dept. of Mathematics=084, Reno, NV 89557-...