In order to model squamous cell carcinoma development in vivo, researchers have long preferred hairless mouse models such as SKH-1 mice that have traditionally been classified as 'wild-type' mice irrespective of the genetic factors underlying their hairless phenotype. The work presented here shows that mutations in the Hairless (Hr) gene not only result in the hairless phenotype of the SKH-1 an...

BACKGROUND Various kinds of alopecia can show small round or oval hairless patch. Dermoscopy could be a simple, useful tool for making a correct diagnosis. OBJECTIVE The aim of this study is to investigate clinical usefulness of dermoscopy for diseases with small round or oval hairless patch on the scalp. METHODS Dermoscopic examination was performed for 148 patients with small round or ova...

The basic helix-loop-helix proteins of the Enhancer of split complex constitute a link between activation of the transmembrane receptor Notch and the resulting effects on transcription of downstream genes. The Suppressor of Hairless protein is the intermediary between Notch activation and expression of all Enhancer of split genes even though individual genes have distinct patterns of expression...

Various forms of ectodermal dysplasia (ED) have been identified in animals. These animal models of ED may help in our understanding of the pathogenesis of ED and the development of novel therapeutic approaches. Mice, dogs, and cattle with mutations in the X-linked EDA gene have been reported and show clinical features that closely resemble X-linked hypohidrotic ectodermal dysplasia in humans. W...

A lethal locus (1(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett’s dominant suppressor of Hairless ( H ) . Of eight new alleles, seven act as dominant suppressors of H , the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak suppressor of H . Confirming NASH (1970), deletions of 1(2)br7 are dominant ...

The Notch signalling pathway mediates cell-cell communication in a wide variety of organisms. The major components, as well as the basic mechanisms of Notch signal transduction, are remarkably well conserved amongst vertebrates and invertebrates. Notch signalling results in transcriptional activation of Notch target genes, which is mediated by an activator complex composed of the DNA binding pr...

Mice with spontaneous coat mutations are ideal animal models for studying skin development and tumorigenesis. In this study, skin hair growth cycle abnormalities were examined in NIH hairless mice 42 days after birth (P42) by using hematoxylin-eosin (H&E) staining. To examine the gene expression patterns in the skin of mutant mice, the dorsal skin of P42 female NIH mice and NIH hairless mice wa...

We have found prefabrication of hairless radial forearm free flap to be a useful technique for nasal reconstruction. Prior skin grafting and a suitable period of maturation permits safe, reliable surgery. Its use should be considered in those patients whose forehead tissue is not suitable or in whom appropriate distant flaps are not available, as is often the case with hirsute males.

After Melish and Glasgow reported that an experimental infection resembling the scalded-skin syndrome in humans could be produced by certain strains of Staphylococcus aureus in neonatal mice (3) and after the subsequent demonstration that this response was mediated by a soluble protein called exfoliatin (2), it was recognized that Swiss mice became refractory to this toxin about 5 days after bi...

Ethiopia is one of the centers genetic diversity sesame (Sesamum indicum L.). The resources present in country should be explored for local, regional, and international improvement programs to design high-performing market-preferred varieties. This study’s objective was determine extent variation among 100 diverse cultivated germplasm collections using phenotypic traits simple sequence repeat (...