PURPOSE We address the question whether lamivudine treatment modulates serum concentrations of hyaluronic acid and whether the pre-treatment HA level can give the information about the presumptive result of treatment and whether HA level evaluation can be useful in monitoring the antiviral therapy in chronic hepatitis B. MATERIAL AND METHODS Forty-nine patients, 31 man, aged 40 +/- 2.5 years ...

An affinity immunological procedure for hyaluronic acid detection on tissue sections is described. This new, sensitive, and specific technique is based on the high affinity of hyaluronectin for hyaluronic acid, utilizing anti-hyaluronectin-hyaluronectin immune complexes. Elimination of binding when the reagent was supplemented with hyaluronic acid or when Streptomyces hyaluronidase-digested tis...

background: cervical cancer is one of the most common types of women’s reproductive cancers. a major risk factor for cervical cancer is exposure to a group of common sexually transmitted viruses called human papillomavirus  (hpv). the over expression of hpv 16 i.e., e6 antigen in the tumors of suspected cervical cancer tissues. however e-6 antigen has hyaluronan binding protein site. methods: t...

Previous studies from several laboratories have provided evidence that interaction of hyaluronan (HA) with the surface of endothelial cells may be involved in endothelial cell behavior. We have recently characterized a mAb, mAb IVd4, that recognizes and neutralizes HA-binding protein (HABP) from a wide variety of cell types from several different species (Banerjee, S. D., and B. P. Toole. 1991....

The addition of hyaluronate to intact chick embryonic heart fibroblasts enriched with a hyaluronate-binding protein (HABP) stimulated phosphorylation of tyrosine and serine/threonine residues in cellular proteins. A protein complex containing a hyaluronate-binding protein (cell-HABP) was isolated from the cultured heart fibroblasts. The isolated complex (Mr approximately 1 x 10(6] contained pho...

Background and Aims: The contribution genetic and antigenic diversity of H9N2 influenza viruses in evading from immune responses, cytotoxic T lymphocytes (CTL) epitopes in hemagglutinin (HA) protein restricted by HLA binding peptides was identified. Materials and Methods: Phylogenetic analyses were carried out for all of full length HA and deduced amino acid sequences of H9N2 viruses available ...

background and aims: the contribution genetic and antigenic diversity of h9n2 influenza viruses in evading from immune responses, cytotoxic t lymphocytes (ctl) epitopes in hemagglutinin (ha) protein restricted by hla binding peptides was identified. materials and methods: phylogenetic analyses were carried out for all of full length ha and deduced amino acid sequences of h9n2 viruses available ...

A complex consisting of the hyaluronic acid-binding region of proteoglycan molecules, the link protein, and hyaluronic acid was purified from trypsin digests of aggregates isolated from the Swarm rat chondrosarcoma. Sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis showed that the molecular weights for the hyaluronic acid-binding region and the link protein were about 67,000 and 4...

Cell contact with the extracellular matrix component hyaluronic acid (HA) plays an important role in many developmental, physiological, and pathological processes, although the regulation of this contact is poorly understood. CD44 proteins carry an amino acid motif that mediates affinity to HA. Artificial clustering of the smallest 85-kD isoform of CD44 (CD44s) has previously been shown to prom...

This study was carried out to assess the localization of hyaluronic acid (HA) and the distribution of glycoproteins in the gastrointestinal system of adult Hyla orientalis. Histochemical analysis of the gastrointestinal system in H. orientalis showed that mucous content included glycogene and/or oxidable dioles [periodic acid/Schiff (PAS)+], neutral or acid-rich (PAS/AB pH 2.5+), sialic acid re...