نتایج جستجو برای: h71
تعداد نتایج: 132 فیلتر نتایج به سال:
Heat shock protein 90 (Hsp90) is an essential molecular chaperone in eukaryotes that facilitates the conformational maturation and function of a diverse protein clientele, including aberrant and/or over-expressed proteins that are involved in cancer growth and survival. A role for Hsp90 in supporting the protein homeostasis of cancer cells has buoyed interest in the utility of Hsp90 inhibitors ...
This paper builds a new microdatabase that covers 100 countries at all income levels and long-run time series in the United States (1870–2010) Mexico ( 1960–2010) to document how modern tax system arises over development. I establish set of stylized facts, which show exemption threshold decreases distribution as country develops, tracking growth employee share employment occurs gradually furthe...
Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these studies demonstrate somatic tumor protein 53 (TP53) mutations are common in JAK2V617F-mutant, pos...
In a Regression Kink (RK) design with a finite sample, a confounding smooth nonlinear relationship between an assignment variable and an outcome variable around a threshold can be spuriously picked up as a kink and result in a biased estimate. In order to investigate how well RK designs handle such confounding nonlinearity, I firstly implement Monte Carlo simulations and then study the effect o...
This paper uses a direct-projections approach to estimate the effect of capital gains taxation on realizations at state level and then develops framework for determining revenue-maximizing rates federal level. We find that elasticity revenues with respect tax rate over 10-year period is −0.5 −0.3, indicating cuts do not pay themselves 5 percentage point increase would yield $18 $30 billion in a...
This paper argues that California’s self-help county tax legislation, which funds additional highway spending, amounts to a natural experiment that can be used to construct a valid instrument to determine highway congestion’s causal effect on the growth rates of GDP, employment, wages, and commodity freight flows for California counties. Our estimation results indicate that highway congestion h...
This short paper estimates the state and local fiscal benefits of the Nurse Family Partnership (NFP) program. NFP provides nurse home visiting services to low-income first-time mothers. In addition to social benefits, NFP provides state and local fiscal benefits by reducing costs of social services, welfare, and crime, and increasing tax receipts due to increased earnings of mothers and former ...
Policies to harmonize value-added tax rates are controversial in the European Union. This paper formulates a multi-country model over a one-dimensional space as a non-cooperative Nash game, in which each country aims at maximizing its tax revenue, subject to the constraint that its tax rate lies within a given common band. Then we examine the e4ects of changes in the common band on tax rates, t...
This paper studies the dynamics by which populations with heterogeneous preferences for public good provision sort themselves into communities. I conduct laboratory experiments to consider which institutions best facilitate efficient self-organization when residents can move freely between locations. I find that institutions requiring all residents of a community to pay equal taxes enable subje...
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