The aim of this study was to validate the Dutch version of the Kessler-10 (K10) as well as an extended version (EK10) in screening for depressive and anxiety disorders in primary care. Data are from 1,607 participants (18 through 65 years, 68.8% female) of the Netherlands Study of Depression and Anxiety (NESDA), recruited from 65 general practitioners. Participants completed the K10, extended w...

BACKGROUND The Internet offers promising possibilities for the quick screening of depression for treatment and research purposes. This paper aims to validate three self-rated measures to screen for depression on the Internet: SID (single-item depression scale), CES-D (Center for Epidemiological Studies Depression scale) and K10 (Kessler psychological distress scale). METHODS Of the 502 subjec...

OBJECTIVES We sought to determine whether screening for anxiety and depression, an emerging risk factor for type 2 diabetes (T2D), adds clinically meaningful information beyond current T2D risk assessment tools. DESIGN Prospective cohort. PARTICIPANTS AND SETTING The 45 and Up Study is a large-scale prospective cohort of men and women aged 45 years and over, randomly sampled from the genera...

Using computer algorithms we establish that the Ramsey number R(3,K10− e) is equal to 37, which solves the smallest open case for Ramsey numbers of this type. We also obtain new upper bounds for the cases of R(3,Kk − e) for 11 ≤ k ≤ 16, and show by construction a new lower bound 55 ≤ R(3,K13 − e). The new upper bounds on R(3,Kk − e) are obtained by using the values and lower bounds on e(3,Kl − ...

Background: Studying medicine is quite challenging as medical students have to work hours and which leads continuous psychological stress a result decrease in sleep duration quality. This study aims determine the prevalence well relationship of academic pattern sleeping problems among students.
 Subjects Methods: In this cross-sectional study,128 non-obese (18 -23 years old, BMI=18.5-24.9)...

The K1 and K10 associated genodermatoses are characterized by clinical symptoms of mild to severe redness, blistering and hypertrophy of the skin. In this paper, we set out to computationally investigate the structural and functional effects of missense mutations on the 2B domain of K1/K10 heterodimer and its consequences in disease phenotype. We modeled the structure of the K1/K10 heterodimer ...

This paper studies the security of a recently-proposed image encryption scheme based on chaos, and points out the following problems: 1) there exist a number of invalid keys and weak keys, and some keys are partially equivalent for the encryption/decryption processes; 2) given one chosen plain-image, a sub-key K10 can be guessed with a smaller computational complexity than that of the simple br...

Keratin 10 (K10) is a type I keratin that is expressed in post-mitotic suprabasal keratinocytes of the skin. Based on cell culture experiments and transgenic mouse studies, it has been proposed that K10 suppresses cell proliferation and tumor formation in the skin. Furthermore, the ability of K10 to suppress cell proliferation was mapped to its unique N- and C-terminal protein domains. In the p...

OBJECTIVE To examine whether human endogenous retrovirus K10 is associated with autoimmune rheumatic disease. DESIGN A novel multiplex reverse transcription polymerase chain reaction (RT-PCR) system was developed to investigate HERV-K10 mRNA expression in patients with rheumatoid arthritis. METHODS 40 patients with rheumatoid arthritis, 17 with osteoarthritis, and 27 healthy individuals wer...

Localization of each keratin isoform differs among epidermal layers. Proliferating basal cells synthesize keratin 14 (K14) and suprabasal cells express keratin 10 (K10) in normal skin. Notch signaling is essential for keratinocyte differentiation. Notch1 is expressed in all epidermal layers, Notch2 in the basal cell layer and Notch3 in basal cell and spinous cell layers in normal epidermis. It ...