BACKGROUND Polysaccharides from various sources are being considered potential sources for the treatment of liver cancer. The aim of this study was to investigate the impact of polysaccharide isolated from Panax notoginseng (PPN) on the proliferation of H22 liver cancer cells and the survival of the tumor-bearing mice transplanted with H22 cells. MATERIALS AND METHODS Polysaccharide from PPN ...

Acute myeloid leukemia (AML) cells of subtypes M4 and M5 show enhanced expression of CD64 (FcgammaRI), the high-affinity receptor for IgG, which is normally expressed at high levels only on activated cells of the myeloid lineage. CD64 is therefore a prime target for the specific delivery of cytotoxic agents. A promising toxin candidate is granzyme B, a human serine protease originating from cyt...

To assess inhibition mechanisms of a Phellinus igniarius (PI) extract on cancer, C57BL/6 mice were orally treated with PI extractive after or before implanting H22 (hepatocellular carcinoma ) or B16 (melanoma) cells. Mice were orally gavaged with different doses of PI for 36 days 24h after introduction of H22 or B16 cells. Mice in another group were orally treated as above daily for 42 days and...

Background Thymic atrophy was discovered in tumor-bearing mice in recent years. Methods Flow cytometry was carried out including Annexin V-FITC/PI double staining, PI staining, Terminal dUTP nick-end labeling, CD3-FITC/CD19-PE and CD8-FITC/CD4-PE double staining. Enzyme-linked immunosorbent assay and polymerase chain reaction were also investigated. Results According to our experiments, we ...

Although previous studies confirmed that steaming and the fermentation process could significantly improve the cognitive-enhancement and neuroprotective effects of Codonopsis lanceolata, the anti-tumor efficacy of steamed C. lanceolata (SCL) and what mechanisms are involved remain largely unknown. The present study was designed to evaluate the anti-tumor effect in vivo of SCL in H22 tumor-beari...

All linear codes of length 100 over a field F which admit the Higman-Sims simple group HS in its rank 3 representation are determined. By group representation theory it is proved that they can all be understood as submodules of the permutation module FΩ where Ω denotes the vertex set of the Higman-Sims graph. This module is semisimple if charF 6= 2, 5 and absolutely indecomposable otherwise. Al...

Toll-like receptor 5 (TLR5) is overexpressed in several cancers and metastases, and presents an enticing target for molecular imaging of primary tumors. In the present study, 131I-anti-TLR5 monoclonal antibody (mAb) was evaluated for its use as a novel radiotracer for imaging hepatocarcinoma in mice bearing H22 tumors. The expression of TLR5 was analyzed by quantitative polymerase chain reactio...

The controversy of the existence of resonances in H22 ions is revisited. We calculate the hyperspherical adiabatic potential curves for H22. For 4S0 symmetry all the potential curves are repulsive, and thus no bound or resonance states exist. This conclusion contradicts the recent calculations of Sommerfeld et al. [Phys. Rev. Lett. 77, 470 (1996); Phys. Rev. A 55, 1903 (1997)], where a 4S0 reso...