The high level of resistance to the macrocyclic lactones has encouraged the search for strategies to optimize their potential as antiparasitic agents. There is a need for pharmaco-parasitological studies addressing the kinetic-dynamic differences between various macrocyclic lactones under standardized in vivo conditions. The current work evaluated the relationship among systemic drug exposure, ...

BACKGROUND Haemonchus contortus and Trichostrongylus spp. are reported to be the most prevalent and highly pathogenic parasites in livestock, particularly in small ruminants. However, the routine conventional tool used in Malaysia could not differentiate the species accurately and therefore limiting the understanding of the co-infections between these two genera among livestock in Malaysia. Thi...

The immunogenic properties of cysteine proteases obtained from excretory/secretory products (ES) of Haemonchus contortus were investigated with a fraction purified with a recombinant H. contortus cystatin affinity column. The enrichment of H. contortus ES for cysteine protease was confirmed with substrate SDS-PAGE gels since the cystatin-binding fraction activity was three times higher than tot...

Haemonchus placei in cattle has never been completely described, possibly due to great morphological similarity with small ruminants Haemonchus contortus. It is newly described on one isolate from Argentina. It has clear distinct morphological features from sheep and goats Haemonchus contortus and presents only two female morphotypes (linguiform and knobbed) instead of three recorded in H. cont...

Gastro-intestinal nematodes in ruminants, especially Haemonchus contortus, are a global threat to sheep and cattle farming. The emergence of drug resistance, and even multi-drug resistance to the currently available classes of broad spectrum anthelmintics, further stresses the need for new drugs active against gastro-intestinal nematodes. A novel chemical class of synthetic anthelmintics, the A...

background: in order to deworm the ruminants especially of sheep in iran, consumption of benzimi­dazoles has more than 2 decades history and today farmers are using imidazothiazoles, macrocyclic lactones and mostly benzimidazole compounds (bzs) to treat infected farm animals. it has been demonstrated that the most common molecular mechanism leading to bzsresistance in haemonchus contortus is a ...

Vaccination with DNA vaccines derived from adult H. contortus induces significant level of protection against homologous infection in goat. To date however, mechanism of protection is not well understood, especially in goat. In this study, HC58 DNA vaccinated goats were artificially infected with 5, 000 dose of infective H. contortus L3 (third larval stage), and cellular immune responses and ab...

Haemonchosis is a very common disease in small ruminants caused by H. contortus, a blood sucking parasite causing anaemia that may be fatal particularly to young animals. Therefore, detection of the infection during prepatent period is important for early treatment. Excretory-Secretory (ES) protein of H. contortus was purified through immunoaffinity chromatography. Dot -ELISA was performed with...

over one-year period, 150 pasture soil samples and 138 sheep faecal samples, collected from different parts of iran were screened for the presence of nematophagous fungi. the samples were cultured at 25ºc on chloramphenicol-2% water agar (chf-wa) plates in the presence of haemonchus contortus third stage larvae (l3) and checked over a two-month period for characteristic conidia, conidiophores a...

2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabenda...