Quinazolines exhibit various biological activities. In the present investigation a series of new 2-amino-5-aryl5,6-dihydro7-(naphthalen-2-yl)quinazolin-4-ols are synthesized by the condensation of various naphthyl substituted cyclohexenones with guanidine in presence of NaOEt. All the synthesized compounds are characterized by various spectral techniques.

Polycyclic guanidine natural products, such as batzelladines A, E, and F, exhibit a rich and diverse array of interesting biological activities (Figure 1). Some polycyclic guanidine alkaloids have been shown to inhibit protein–protein interactions, including the binding of HIV gp120 to CD4 on human T-cells. Furthermore, many polycyclic guanidines display potent antiviral, antimalarial, and immu...

A new series of fourteen dicationic flexible triaryl bis-guanidines 3a,b, bis-N-substituted guanidines 7a,b and 8a,b as well as bis-imidamides 9-12a,b having a 1,3- or 1,4-diphenoxybenzene scaffold backbone were synthesized. The in vitro activity of the novel dications as antiprotozoal agents against Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum (P.f.) was assessed. Interest...

In the title compound, C(20)H(15)Cl(2)N(3)O, a typical polysubstituted guanidine with normal geometric parameters, the torsion angles [C-N-C-O = 3.8 (2), N-C-N-C = -6.1 (2)°] indicate that the guanidine and carbonyl groups are almost coplanar, due to the pseudo-hexa-gonal ring formed by intra-molecular N-H⋯O hydrogen bonds. The crystal packing is stabilized by inter-molecular N-H⋯O hydrogen bon...

Hexasubstituted guanidinium moieties have been used as ionic liquid tags for organocatalyts for the first time. Such conjugates were obtained in the (S)-proline and (S)-pyrrolidine-2-ylmethyl series by alkylation reactions of pentasubstituted guanidines. The resulting guanidinium-tagged organocatalysts were applied to asymmetric direct aldol reactions providing high stereoselectivities and yiel...

Considerable attention has been focused on the biological activity of guanidine derivatives from two main directions. Ever since the original report by Watanabe of the hypoglycemic properties of guanidine (3), derivatives of this compound have been investigated as possible therapeutic agents for the control of diabetic hyperglycemia. At least three such compounds, Synthalin (decamethylenediguan...

Aromatic secondary amides such as benzanilide (1) exist in a trans-amide form both in the crystal and in the solution, whereas N-methylbenzanilide (2) exists in cis form in the crystal, and predominantly in a cis form in the solution. Similar cis conformational preferences were observed in aromatic N,N'-dimethylated ureas and guanidines, in which two aromatic rings are located face to face. The...