This paper focuses on numerical the prediction of multiaxial static strength lattice structures. We analyze a body-centered cubic cell printed with Selective Laser Melting in AlSi10Mg aluminum alloy. Parent material is experimentally characterized, and Gurson-Tveergard-Needleman (GTN) damage model calibrated to predict failure simulations. The GTN used structures exhibiting brittle localized fr...

A novel micromechanics based damage model is proposed to address failure mechanism of defected solids with randomly distributed penny-shaped cohesive micro-cracks (Barenblatt–Dugdale type). Energy release contribution to the material damage process is estimated in a representative volume element (RVE) under macro hydrostatic stress state. Macro-constitutive relations of RVE are derived via self...

Under warm forming, the damage parameters of extended GTN model are easily affected by temperature, and failure materials under forming is less studied using this model. In paper, based on model, DP590 at different temperatures determined experiment numerical simulation, studying trend changing with temperature. Through analysis shear specimens angles temperatures, we changes in void conditions...

The present work addresses the micromechanical modeling and simulation of crack initiation propagation in ductile materials failing by void nucleation, growth coalescence. A cohesive–volumetric approach is used overall material behavior characterized both a hardening bulk constitutive law softening surface traction–separation embedded between each mesh finite element discretization. sums up acr...

Glyceryl trinitrate (GTN) was previously reported to induce hepatocellular carcinoma (HCC) in rats after prolonged feeding. The present experiments were undertaken to evaluate the histogenesis and molecular biology of these tumors and the possible role of nitric oxide (NO), a GTN metabolite, in their development. Male F344 rats received a single i.g. intubation of GTN (1.2 g/kg) at 6 weeks of a...

An experimental model of headache offers unique possibilities to study the mechanisms responsible for head pain. Using the glyceryl trinitrate [GTN; nitric oxide (NO) donor] model of experimental headache, we studied the intensity, quality and time profile of headache after infusion of GTN in 16 patients with chronic tension-type headache and in 16 healthy controls. Subjects were randomized to ...

Bioactivation of nitroglycerin (GTN) into an activator of soluble guanylate cyclase (sGC) is essential for the vasorelaxant effect of the drug. Besides several enzymes that catalyze GTN bioactivation, the reaction with cysteine is the sole nonenzymatic mechanism known so far. Here we show that a reaction with ascorbate results in GTN bioactivation. In the absence of ascorbate, GTN did not affec...