In this paper, we present our work on two aspects of multimedia adaptation: knowledge-based single media adaptation and semantic adaptation of multimedia documents. For the former, we propose support of adaptation by direct hinting in the scope of MPEG-21. For the latter, which is the main part of the presented work, we introduce the description of semantic dependencies between media objects of...

Within an MPEG-21 architecture, the two key concepts are the Digital Item, representing multimedia content, and Users, interacting with this content. MPEG-21 introduced Digital Item Processing to allow content authors to describe suggested processing of their Digital Items. It standardizes ways to insert functionality into a Digital Item, as such, creating a dynamic and interactive multimedia f...

Genetic modification of whole-cell cancer vaccines to augment their efficacies has a history of over two and a half decades. Various genes and gene combinations, targeting different aspects of immune responses have been tested in pursuit of potent adjuvant effects. Here we show that co-expression of two cytokine members of the common cytokine receptor γ-chain family, IL-21 and IL-7, in whole-ce...

Writing Committee: Peter E. Clayton, Royal Manchester Children’s Hospital, Manchester, United Kingdom; Walter L. Miller*, University of California, San Francisco, California; Sharon E. Oberfield, Columbia University, New York, New York; E. Martin Ritzén, Karolinska Institute, Stockholm, Sweden; Wolfgang G. Sippell*, University Children’s Hospital, Kiel, Germany; Phyllis W. Speiser, New York Uni...

Received: April 1, 2009 Accepted: May 13, 2009 Correspondence: Dr. Keisuke Nagasaki, Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medicine and Dental Sciences, 1-757 Asahimachi, Niigata 951-8510, Japan E-mail: [email protected] H62L Mutation of CYP21A2 Identified in the Non-classical Form of 21-Hydroxylase Deficiency

congenital hepatic fibrosis (chf) is a rare disease that affects both the liver and kidneys.  congenital hepatic fibrosis (chf) is an autosomal recessive inherited malformation defined pathologically by a variable degree of periportal fibrosis and irregularly shaped proliferating bile ducts. affected individuals also have impaired renal function, usually caused, in children and teenagers, by an...