Regulated auxin patterning provides a key mechanism for controlling root growth and development. We have developed a data-driven mechanistic model using realistic root geometry and formulated a principle to theoretically investigate quantitative auxin pattern recovery following auxin transport perturbation. This principle reveals that auxin patterning is potentially controlled by multiple combi...

Risk-reducing salpingo-oophorectomy (RRSO) is the cornerstone of ovarian cancer prevention in BRCA1/2 mutation carriers. Occult fallopian tube and ovarian cancers have been reported in a small percentage of BRCA1/2 mutation carriers undergoing RRSO. Here, we review our single-institution experience with RRSO in BRCA1/2 mutation carriers to characterize cases of microscopic cancers in these pati...

a r t i c l e i n f o We examine the role of substitution from traditional to modern energy carriers and of differential rates of innovation in the use of each of these in economic growth in Sweden from 1850 to 1950. We use a simple growth model with a nested CES production function and exogenous factor-augmenting technological change and carry out a counterfactual simulation based on the econo...

Purpose: Evaluating whether and how anxious depressive symptoms change from prior to Oncological Genetic Counseling (OGC) one month following BRCA genetic test result. Short-term psychological impact of disclosure in an Italian sample was also assessed. Methods: 106 natives completed Hospital Anxiety Depression scale (HADs) both before accessing OGC (t1) their result (t2). In t2 they the transl...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

Auxin is an essential hormone for plant growth and development. Auxin influx carriers AUX1/LAX transport auxin into the cell, while auxin efflux carriers PIN pump it out of the cell. It is well established that efflux carriers play an important role in the shoot vascular patterning, yet the contribution of influx carriers to the shoot vasculature remains unknown. Here, we combined theoretical a...

nasal mupirocin is found to eradicate effectively methicillin-resistant staphylococcus aureus (mrsa) from colonized patients, but there are concerns about resistant strains. the aim of this study was to detect the mupirocin resistance and nasal carriage of methicillin resistant s. aureus among healthcare workers (hcws) at the university hospitals of tehran.totally 270 nasal swabs were collected...

The therapeutics of tumor is largely confined upon directly encountering the tumor cells. The current cytostatic agents mainly interfere with processes involved in cell growth while the aim in immunotherapy is to make immune effector cells to selectively attack the tumor cells. A recent approach to fight tumor is to impede and interfere with its blood supply, i.e., turning off angiogenesis or n...

Background Ghezel sheep are highly prolific and one of the local sheep breeds in Iran and Turkey. Growth differentiation factor-9 (GDF9) gene has been found to be essential for growth and differentiation of early ovarian follicles. Novel mutations in GDF9 have been associated with increased ovulation rates and high litter sizes in heterozygous carriers. Therefore, fecundity gene for GDF9 (FecGH...