OBJECTIVES Noise reduction using wavelet thresholding of multitaper estimators (WTME) and geometric approach to spectral subtraction (GASS) can improve speech quality of noisy sound for speech coding strategy. This study used Perceptual Evaluation of Speech Quality (PESQ) to assess the performance of the WTME and GASS for speech coding strategy. METHODS This study included 25 Mandarin sentenc...

A recent study carried out at the University of California, Irvine exemplifies a commonly overlooked ethical conundrum of neuroimaging research: incidental findings. Research study designs must address the potential of uncovering unexpected findings in subjects during the study and delineate a protocol for reporting and initiating treatment. We urge the community to petition their home institut...

1168 Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: fi ndings from the Women’s Health Initiative Rebecca L. Drieling, MPH, PhD, Andrea Z. LaCroix, PhD, MPH, Shirley A.A. Beresford, PhD, MS, Denise M. Boudreau, PhD, Charles Kooperberg, PhD, Rowan T. Chlebowski, MD, PhD, Margery Gass, MD, Carolyn J. Crandall, MD, MS, Catherine R. Womack,...

BACKGROUND Although there is substantial concern about negative attitudes to mental illness, little is known about the stigma associated with Generalised Anxiety Disorder (GAD) or its measurement. The aim of this study was to develop a multi-item measure of Generalised Anxiety Disorder stigma (the GASS). METHODS Stigma items were developed from a thematic analysis of web-based text about the ...

Using RefSeq annotations, most disease/trait-associated genetic variants identified by genome-wide association studies (GWAS) appear to be located within intronic or intergenic regions, which makes it difficult to interpret their functions. We reassessed GWAS-Associated single-nucleotide polymorphisms (herein termed as GASs) for their potential functionalities using integrative approaches. 8834...

PURPOSE To evaluate the functional and anatomical outcome after intravitreal ranibizumab injection in 2 patients with cystoid macular edema (CME) related to Irvine-Gass syndrome. METHODS Two patients with pseudophakic CME refractory to current standard topical treatment were enrolled in this study. Intravitreal (0.5 mg/0.05 mL) ranibizumab injection was performed. Baseline visits included bes...

BACKGROUND Variation in clinical practice in the perioperative environment and intensive care unit is a major challenge facing modern medicine. The objective of the present study was to analyse intraoperative crystalloid administration practices at two academic medical centres in the USA. METHODS We extracted clinical data from patients undergoing intra-abdominal procedures performed at UC Ir...