Based on the structures of identified active ingredients, the phenolic compounds extracted from grape seeds and pine bark would not be expected to be genotoxic. Indeed, the inventor of pycnogenol states that this product was tested in Salmonella typhimurium and was negative. Substantial health claims for grape seed and pine bark extracts, including some studies showing tumor inhibition, make th...

Grape marc seeds contain large amounts of different polyphenolic compounds so they can be used for the recovery of these classes of compounds. A new green extraction method for the recovery of phenols from the grape seeds was developed. To provide a high quality extract sourced from natural product by using enzymes as alternative solvents and spending less energy, it is impeccable to call this ...

The effect of increasing concentration of ethanol (0, 4, 7.5 and 13 %) and contact time (respectively 1, 4, 7 and 10 days) on the extraction of phenolics from berry skins and seeds of the grape, Vitis vinifera 'Aglianico' and 'Uva di Troia', were examined. Two assays of post-fermentative maceration in two hydroalcoholic solutions at 11 and 13 % ethanol, were also performed. Chromatic properties...

The aim of this work was to apply unconventional extraction methods including ultrasonication (US), high voltage electrical discharge (HVED) and pulsed electric field (PEF) to extract polyphenols from grape seeds and concentrate the extracts by ultrafiltration. A comparative evaluation of the three extraction methods for release of polyphenols from grape seeds was investigated. The results show...

The effects of grape seeds extract and grape peels extract prepared from grape pomace on the activity of antioxidant enzymes, degree of lipid peroxidation in serum and liver tissue were investigated in rabbits fed on high cholesterol diet. New Zealand white rabbits were divided as follows ; 1) NOR (normal group); 2) CHOL (cholesterol group); 3) GSH (cholesterol + grape seed extract group); 4) G...

Grape proanthocyanidins (PAs) play a major role in the organoleptic properties of wine. They are accumulated mainly in grape skin and seeds during the early stages of berry development. Despite the recent progress in the identification of genes involved in PA biosynthesis, the mechanisms involved in subunit condensation, galloylation, or fine regulation of the spatio-temporal composition of gra...

Background Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system .The present study investigates the efficacy grape seeds , source of the most useful groups of plant flavonoids, phenolic procyanids, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. MaterialsAndMethods A total of 32 m...

The subcritical water extraction (SWE) is a high-efficiency and environment-friendly extraction method. The extraction of resveratrol (RES) of grape seeds obtained from the wine production process was proposed using subcritical water extraction (SWE). The effects of different extraction process parameters on RES yield were investigated by single factors. Extraction optimization was conducted us...