Several reports have shown the various effects of grape (Vitis vinifera) seed extract such as antioxidant, hypotensive, hypolipidemic and vasodilatory effects. The aim of present study was to investigate the effect of grape leaf hydroalcoholic extract on isolated rat tracheal contractions induced by KCl and acetylcholine. The trachea was removed from male adult Sprague-Dawley rat and placed in ...

The present study is aimed at investigating the effect of nicotine administration on carbohydrate metabolic enzymes in the brain tissue of male albino rat. In vitro studies showed that Red grape (Vitis vinifera) has significant antioxidant activity, antimicrobial, anti-inflammatory action. Nicotine induces oxidative stress both in vivo and in vitro that causes a peroxidant/antioxidant imbalance...

In one study, 287 patients diagnosed with asymptomatic carotid plaques or abnormal plaque free carotid intima-media thickness (CIMT) were randomly assigned to a GSE group (n = 146) or control group (n = 141). As anticipated, after treatment, GSE resulted in significant reduction in MMCIMT progression, while MMCIMT and plaque score were stable and even increased with the control group. The numbe...

PURPOSE To verify the effect of consumption of grape extract isolated or combined with α-tocopherol supplementation on atherosclerosis model with Apo E -/- mice. METHODS After six weeks of atherogenic diet, Apo E -/- mice were divided into the following groups: Control, Grape, Tocopherol and Grape plus Tocopherol. The treatment progressed for 11 weeks when animals were submitted to euthanasia...

many studies have been performed for treatment or prevention of pulmonary fibrosis. however, no effective treatment has been found yet. the aim of this study was to investigate the effect of grape seed extract on bleomycin-induced lung fibrosis in rat. hydroalcoholic extract of grape seed (vitis vinifera) was prepared using maceration method. nmri rats weighing 250-300 g were given single intra...

The aim of current research was to develop a water-in-oil emulsion containing grape seed extract for application in cosmeceuticals. Finally grinded dried grape seeds powder was extracted with hydro alcoholic mixture. Emulsions consisting of different concentrations of cetyl dimethicone (Abile EM90), the nonionic emulsifier, liquid paraffin as oily phase and water as aqueous phase were developed...

Grape-seed proanthocyanidins’ role as stimulators of active GLP-1 in rats suggests that they could be effective as satiating agents. Wistar rats were used to study the effects of proanthocyanidins on food intake with different doses, administration times and proanthocyanidin extract compositions. A dose of 423 mg of phenolics per kg body weight (BW) of grape-seed proanthocyanidin extract (GSPE)...

several reports have shown the various effects of grape (vitis vinifera) seed extract such as antioxidant, hypotensive, hypolipidemic and vasodilatory effects. the aim of present study was to investigate the effect of grape leaf hydroalcoholic extract on isolated rat tracheal contractions induced by kcl and acetylcholine. the trachea was removed from male adult sprague-dawley rat and placed in ...

introduction: excessive physical exercise overproduces reactive oxygen species. even if elite sportsmen increase their antioxidant status by regular physical training, this improvement is not sufficient to limit free radical production during the competition period which can be detrimental to the body. this study evaluates the effect of grape seed supplementation along with aerobic exercise on ...