نتایج جستجو برای: granisetron

تعداد نتایج: 646  

Background Granisetron is a first-generation 5-HT3-receptor antagonist that has shown efficacy in preventing postoperative nausea and vomiting (PONV). In this randomized double-blind parallel-group clinical trial, we assessed the efficacy of generic granisetron versus Kytril®, in the prevention of PONV in patients undergoing general anesthesia for gynaecological surgeries. Method One hundred an...

Journal: :Biological & pharmaceutical bulletin 2017
Mayako Uchida Yasuo Mori Tsutomu Nakamura Koji Kato Kenjiro Kamezaki Katsuto Takenaka Motoaki Shiratsuchi Kaori Kadoyama Toshihiro Miyamoto Koichi Akashi

In the present study, the antiemetic effect of palonosetron, not combined with dexamethasone and aprepitant, on chemotherapy-induced nausea and vomiting was evaluated in patients with malignant lymphoma receiving first-line rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy, and was compared to that of granisetron. A total of 74 patients with non-Hodgkin lymp...

2010
Sanjeev Kumar V. Vernekar Hasan Y. Hallaq Guy Clarkson Andrew J. Thompson Linda Silvestri Sarah C. R. Lummis Martin Lochner

This report describes the synthesis and biological characterization of novel granisetron derivatives that are antagonists of the human serotonin (5-HT(3)A) receptor. Some of these substituted granisetron derivatives showed low nanomolar binding affinity and allowed the identification of positions on the granisetron core that might be used as attachment points for biophysical tags. A BODIPY fluo...

Journal: :Anesthesiology 1996
G D Cieslak M F Watcha M B Phillips J H Pennant

BACKGROUND Postoperative nausea and vomiting (PONV) may delay discharge from hospital after ambulatory surgery. The antiserotonin agents, ondansetron and granisetron, provide effective prophylaxis against chemotherapy-induced and postoperative nausea and vomiting in adults, but are expensive. We determined the dose-response relation of granisetron and the financial impact of using this drug in ...

2016
Carmela Nacci Margherita Fanelli Maria Assunta Potenza Valentina Leo Monica Montagnani Maria Antonietta De Salvia

AIM To investigate the mechanisms underlying the potential contribution of the heme oxygenase/carbon monoxide (HO/CO) pathway in the constipating effects of granisetron. METHODS For in vivo studies, gastrointestinal motility was evaluated in male rats acutely treated with granisetron [25, 50, 75 μg/kg/subcutaneous (sc)], zinc protoporphyrin IX [ZnPPIX, 50 μg/kg/intraperitoneal (ip)] and hemin...

2017
Tarun Tyagi Shashikant Shinde

BACKGROUND: Pain on injection is one of the most commonly reported side effect of Propofol, there are numerous pharmacological and non pharmacological methods to reduce it. This study compares the efficacy of intra-venous Granisetron with normal saline pre-treatment to reduce pain on propofol treatment, measured on verbal rating pain scale. MATERIAL & METHODS: It was a double blind randomized c...

Journal: :The British journal of ophthalmology 2001
Y Fujii H Tanaka M Ito

BACKGROUND/AIMS Postoperative vomiting occurs frequently after strabismus surgery in children. Granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, is effective for the prevention of vomiting following paediatric strabismus surgery. Ramosetron, another new antagonist of 5-hydroxytryptamine type 3 receptor, has more potent and longer acting properties than granisetron against...

Journal: :Archives of surgery 2001
Y Fujii H Tanaka T Kawasaki

HYPOTHESIS Laparoscopic cholecystectomy is associated with a relatively high incidence of postoperative nausea and vomiting when no prophylactic antiemetic is given. This study assesses the efficacy and safety of oral granisetron hydrochloride for the prevention of nausea and vomiting after laparoscopic cholecystectomy. DESIGN A prospective, randomized, double-blind, placebo-controlled study....

2002
Y. FUJII H. TOYOOKA H. TANAKA

We have compared the efficacy of granisetron in combination with dexamethasone with each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double-blind study, 120 patients (85 females) received granisetron 3 mg, dexamethasone 8 mg or granisetron 3 mg with dexamethasone 8 mg i.v. (n 40 in each group), immediately before induction ...

Journal: :British journal of anaesthesia 1998
Y Fujii H Toyooka H Tanaka

This study was undertaken to determine the minimum effective dose of granisetron, a selective 5-hydroxytryptamine type 3 receptor antagonist, for the prevention of postoperative nausea and vomiting (PONV) after middle-ear surgery. In a randomized, double-blind, placebo-controlled trial, 120 women (ASA I) received placebo (saline) or granisetron at three different doses (20 micrograms kg-1, 40 m...

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