Iron overload is known to occur in the West European and American population due to the consumption of iron-rich diets. On the other hand, genetic disorders leading to iron overload are also known. Iron overload leads to increased peroxidation and disruptive disintegration of lipid-rich membranes, and predisposes humans for an enhanced risk of cancer induction. In experimental animals iron ...

Background: Iron overload can cause many complications and damage many organs as well as physiologic functions. Consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. The aim of this review is to investigate hydrophilic phytochelators in iron overload condition. Methods: In this review, the possible ...

This proposal presents MSA, a uniprocessor, single address space resource scheduling algorithm. MSA addresses the open research problem of explicit dynamic memory management in a resource-constrained real-time utility accrual environment. As an overload scheduler, the algorithm ensures graceful performance degradation as defined by a set of optimality criteria. MSA extends the scope of resource...

important factor in the prevention of industrial accidents involve of the ability of employees to maintain awareness of the work situation, understand the information it holds, and predict how situations will develop. in this study, we examined the role of fatigue and work overload in predicting work situation awareness among workers. the current study was a cross-sectional study. the sample co...

backgrounds: situation awareness is an important factor in industrial accidents. improving situation awareness may help to prevent occupational accidents. determination of factors influencing situation awareness will help to plan and take measures for betterment of working condition and development of a safer workplace. in this study, we examined the role of work overload and job stress in pred...

transfusion-dependent patients such as those suffering from β-thalassaemia develop a fatal secondary haemosiderosis and consequently a selective iron chelator must be used to relieve such iron overload. 3- hydroxypyridin-4-ones are selective for iron(iii) under most biological conditions, but unlike desferrioxamine, are efficiently absorbed when administered orally. in this study, the synthesis...

iron overload is a serious clinical condition which can be largely prevented by the use of iron-specific chelating agents. in this study, the synthesis and determination of partition coefficients (kpart) of a range of n-alkyl hydroxypyridinones, as orally active iron chelators, are described. synthesis of n-aryl hydroxypyridinones was achieved via a single step synthetic pathway. in this method...

background: patients with transfusional iron overload have depended on iron chelation therapy and improving chelation regimens have been of the highest priority. the aim of this study was to compare effect of combined versus monotherapy with deferoxamine (dfo) and deferiprone (dfp) in iron overloaded beta thalassemia (bt) major patients materials and methods we studied 36 bt major patients (mea...