In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral immune response. In this study we identify TRIM68, a close homologue of TRIM21, as a novel regulator of Toll-like receptor (TLR)- and RIG-I-like recep...

Anaplastic large cell lymphoma (ALCL) is associated with the t(2;5)(p23;q35), which generates the NPM-ALK fusion gene encoding an 80-kD protein. Several studies have suggested that genes other than NPM may be fused to the ALK gene. Here we have identified TRK-fused gene (TFG) as a new ALK partner in 2 ALCL, 1 of which exhibited a t(2;3)(p23;q21). In these cases, TFG was involved in 2 different ...

The present study was designed to explore the combined effects of a conventional antidiabetic drug, metformin (MET) and Gymnema sylvestre (GS) or Trigonella foenum graecum (TFG) extract in alloxan (ALX, 150 mg / kg body weight, IP)-induced swiss albino mice. Other than serum glucose, changes in total serum cholesterol (TC), triglyceride (TG), urea, α-amylase and alkaline phosphatase (ALP) level...

Trigonella foenum-graecum (fenugreek) seeds have previously been shown to have hypoglycemic and hypocholesterolemic effects on type 1 and type 2 diabetes mellitus patients and experimental diabetic animals. The Trigonella foenum-graecum extract has now been investigated for its effects on general properties, blood glucose and blood lipid, and hemorheological parameters in experimental diabetic ...

The present study was taken up to evaluate the efficacy of Trigonella foenum graecum and Coccinia indica individualy and in combination in streptozotocin induced diabetic rats for a period of 90 days. The various groups in this study included normal control (Group-I), diabetic control (Group-II), diabetic rats treated with Trigonella foenum graecum (Group-III), diabetic rats treated with Coccin...

BACKGROUND Cell-size-control systems, coupled with apoptotic- and cell-proliferation-regulatory mechanisms, determine the overall dimensions of organs and organisms, and their dysregulation can lead to tumor formation. The interrelationship between cell-growth-regulatory mechanisms and apoptosis during normal development and cancer is not understood. The TRK-fused gene (TFG) promotes tumorigene...

An all-fiber normal-dispersion Yb-doped fiber laser with 45°-tilted fiber grating (TFG) is, to the best of our knowledge, experimentally demonstrated for the first time. Stable linearly-chirped pulses with the duration of 4 ps and the bandwidth of 9 nm can be directly generated from the laser cavity. By employing the 45° TFG with the polarization-dependent loss of 33 dB, output pulses with high...

In this article, we have theoretically and experimentally investigated the unique vector refractive index (RI) sensing property of tilted fiber grating (TFG). Due to orthogonal symmetric structure, TFGs would mainly achieve coupling between core mode two polarization LP1m cladding mode. And numerical simulation results showed that coefficient fundamental is higher than others. experiment, furth...

We prove that the common theory Tfg of nonabelian groups has the dimensional order property, or DOP, implying, for example, that there is no reasonable structure theorem for א1-saturated models of Tfg.

Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER) and ER exit ...