نتایج جستجو برای: gpi

تعداد نتایج: 4043  

2016
RONG FU SHAO-XUE DING YI LIU LI-JUAN LI HUI LIU HONG-LEI WANG TIAN ZHANG ZONG-HONG SHAO

Paroxysmal nocturnal hemoglobinuria/aplastic anemia (PNH/AA) syndrome presents a markedly increased population of cells deficient in glycophosphatidylinositol (GPI- cells) and signs of bone marrow failure, which requires treatment with hematopoiesis-stimulating factors, such as granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF). However, little is known about the effects o...

Journal: :The Journal of biological chemistry 2006
Saulius Vainauskas Anant K Menon

Glycosylphosphatidylinositol (GPI) anchoring of proteins is catalyzed by GPI transamidase (GPIT), a multisubunit, endoplasmic reticulum (ER)-localized enzyme. GPIT recognizes ER-translocated proteins that have a GPI-directing C-terminal signal sequence and replaces this sequence with a preassembled GPI anchor. Although the GPI signal sequence has been extensively characterized, little is known ...

Journal: :Circulation 1999
K D O'Brien C Pineda W S Chiu R Bowen M A Deeg

BACKGROUND Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) may play an important role in inflammation, because it can hydrolyze the GPI anchors of several inflammatory membrane proteins (eg, CD106, CD55, and CD59) and its hydrolytic products upregulate macrophage cytokine expression (eg, interleukin-1 and tumor necrosis factor-alpha). Because of its potential regulatory role in ...

2015
Ming Zong Tianbao Lu Shasha Fan Hui Zhang Ruhan Gong Lishan Sun Zhiyan Fu Lieying Fan

INTRODUCTION Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of glucose 6-phosphate isomerase (GPI) in the proliferation of RA-FLS. METHODS The distribution of GPI in synovial tissues from RA and osteoarthritis (OA) patients was examined by immunohistochemical analysis. FLS were isolated and c...

Journal: :Blood 2007
Janine J J Hulstein Peter J Lenting Bas de Laat Ron H W M Derksen Rob Fijnheer Philip G de Groot

Patients with antiphospholipid syndrome are characterized by the association of thrombosis or pregnancy morbidity and the presence of antiphospholipid autoantibodies. Particularly, anti-beta(2)-glycoprotein (beta(2) GPI) autoantibodies correlate with thrombosis, suggesting an antibody-induced gain of prothrombotic function and/or an antibody-induced loss of antithrombotic function of beta(2) GP...

Journal: :The Journal of biological chemistry 1997
N Garg R L Tarleton K Mensa-Wilmot

Glycosylphosphatidylinositols (GPIs) are membrane anchors for cell surface proteins of several major protozoan parasites of humans, including Trypanosoma cruzi, the causative agent of Chagas' disease. To investigate the general role of GPIs in T. cruzi, we generated GPI-deficient parasites by heterologous expression of T. brucei GPI-phospholipase C. Putative protein-GPI intermediates were deple...

Journal: :Blood 1996
H Kanno H Fujii A Hirono Y Ishida S Ohga Y Fukumoto K Matsuzawa S Ogawa S Miwa

We report here two new cases of glucose phosphate isomerase (GPI) deficiency associated with hemolytic anemia and present the results of molecular analysis of the five Japanese GPI variants. A Japanese girl (GPI Fukuoka) had an episode of prolonged neonatal jaundice and at 3 years of age was admitted due to acute hemolytic crisis occurring with upper respiratory tract infection. Red blood cell ...

Journal: :Journal of cell science 1999
M A Ferguson

The discovery of glycosylphosphatidylinositol (GPI) membrane anchors has had a significant impact on several areas of eukaryote cell biology. Studies of the African trypanosome, which expresses a dense surface coat of GPI-anchored variant surface glycoprotein, have played important roles in establishing the general structure of GPI membrane anchors and in delineating the pathway of GPI biosynth...

Journal: :Infection and immunity 2010
J Brian de Souza Manohursingh Runglall Patrick H Corran Lucy C Okell Sanjeev Kumar D Channe Gowda Kevin N Couper Eleanor M Riley

Parasite-derived glycosylphosphatidylinositol (GPI) is believed to be a major inducer of the pathways leading to pathology and morbidity during Plasmodium falciparum infection and has been termed a malaria "toxin." The generation of neutralizing anti-GPI ("antitoxic") antibodies has therefore been hypothesized to be an important step in the acquisition of antidisease immunity to malaria; howeve...

2012
Masanobu Horikoshi Daisuke Goto Seiji Segawa Yohei Yoshiga Keiichi Iwanami Asuka Inoue Yuki Tanaka Isao Matsumoto Takayuki Sumida

OBJECTIVE Invariant natural killer T (iNKT) cells regulate collagen-induced arthritis (CIA) when activated by their potent glycolipid ligand, alpha-galactosylceramide (α-GalCer). Glucose-6-phosphate isomerase (GPI)-induced arthritis is a closer model of human rheumatoid arthritis based on its association with CD4+ T cells and cytokines such as TNF-α and IL-6 than CIA. Dominant T cell epitope pe...

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