Mammalian reproduction requires gonadotropin-releasing hormone (GnRH)-mediated signaling from brain neurons to pituitary gonadotropes. Because the pulses of released GnRH vary greatly in amplitude, we studied the biosynthetic response of the gonadotrope to varying GnRH concentrations, focusing on extracellular-regulated kinase (ERK) phosphorylation and egr1 mRNA and protein production. The over...

With the increasing use of gonadotropin releasing hormone antagonist protocols, it has become an option to trigger ovulation with gonadotropin releasing hormone agonist which has several advantages over human chorionic gonadotropin triggering; among those an elimination or reduction in ovarian hyperstimulation syndrome, and a reduction in luteal phase discomfort. Thus, this paper questions the ...

Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin inhibitory hormone (GnIH) initiated a revolution in the field of reproductive physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine- amide (RFamide)-related peptides (RFRPs), indicated a similar function...

Efficacy of poly (lactic-co-glycolic acid) microparticles as a gonadotropin-releasing hormone analogue delivery system to stimulate ovulation peled Coregonus | Jindriška Knowles, Jakub Vysloužil, Jan Muselík, Vlastimil Stejskal, Kouřil, Peter Podhorec Agricultural Journals