BACKGROUND Male breast cancer is a rare malignancy. Despite the lack of prospectively generated data from trials in either the adjuvant or metastatic setting, patients are commonly treated with hormone therapies. Much controversy exists over the use of gonadotropin-releasing hormone analogues in metastatic male breast cancer patients. We conducted this study to provide more concrete ground on t...

Until 2000 it was believed that gonadotropin-releasing hormone (GnRH) was the sole regulator of hypophyseal gonadotropes. In 2000, the discovery of a gonadotropin inhibitory hormone (GnIH) initiated a revolution in the field of reproductive physiology. Identification of GnIH homologues in mammals, the arginine-phenylalanine- amide (RFamide)-related peptides (RFRPs), indicated a similar function...

The human gonadotropin-releasing hormone (GnRH) precursor consists of the GnRH sequence followed by a 59-amino acid carboxyl-terminal extension. A 56-amino acid peptide within this extension has been shown to stimulate gonadotropin release, and this activity has been localized to its amino-terminal region. A series of seven overlapping peptide fragments corresponding to the first 24 amino acids...

Gonadotropin-releasing hormone (GnRH) is a neuropeptide hormone responsible for the release of luteinizing hormone (Lh) and follicle-stimulating hormone (Fsh) from the anterior pituitary gland . GnRH have been identified and characterized from the brain of C. catla. A cDNA fragment of 202bp was amplified and GnRH variant has been identified in the form chicken-II-type gonadotropin-releasing hor...

Background: There have been reports of transient psychosis in women medicated for gynecologic conditions.Objective: The aim of this paper was to explore this literature.Method: The PubMed and Google Scholar databases were searched for relevant case reports Results: The following reports were found: psychosis induced by gonadotropinreleasing hormone in the treatment of endometriosis, by clomiphe...