synthesis and characterization of two functionalized gold nanoparticles by using of two poly functional amino acids (l-arginine and l-aspartic acid) are reported. the gold nanoparticles were reduced by sodium citrate and functionalized with l-arginine at the ph of 7 and 11 and l-aspartic acid at the ph of 7. transmission electron microscopy, uv-vis spectroscopy, dynamic light scattering, zeta p...

UNLABELLED This study examined the gene transfer efficiency and toxicity of 2-kDa polyethylenimine conjugated to gold nanoparticles (PEI2-GNPs) in the human cornea in vitro and rabbit cornea in vivo. PEI2-GNPs with nitrogen-to-phosphorus ratios of up to 180 exhibited significant transgene delivery in the human cornea without altering the viability or phenotype of these cells. Similarly, PEI2-GN...

The possibility of releasing gold nanoparticles (GNP) into the environment has been 9 rapidly increasing with the wide spread and flourishing application of gold nanoparticles (GNPs) 10 in a wide range of areas. Consequently, environmental effects of GNP, especially toxicities to 11 living organisms have drawn great attention. However, their toxicological characteristics still 12 remain unclear...

BACKGROUND Nanoparticles (a part of matter which size is less than 100 nm) have numerous potential applications in biomedicine, due to their unique surface, electronic and optical properties. The goal of the present study was to examine the distribution of gold nanoparticles (GNPs) in mice after single intravenous administration. METHODS Spherical GNPs were synthesized by chemical reduction o...

Gold nanoparticles (GNPs) have shown promising medical applications in cancer treatment involved in the regulation of intracellular redox balance. Previously, we have reported that GNPs can trigger apoptosis and necrosis in human lung cancer cells (A549) when L-buthionine-sulfoximine (BSO) was used to decrease the expression of intracellular glutathione (GSH). Herein, we investigated the cytoto...

Unlike conventional physical and chemical methods, the biogenic synthesis of gold nanoparticles (GNPs) is considered a green and non-toxic approach to produce biocompatible GNPs that can be utilized in various biomedical applications. This can be achieved by using plant-derived phytochemicals to reduce gold salt into GNPs. Several green synthesized GNPs have been shown to have antibacterial eff...

The development of eco-friendly approach for the preparation of monodispersed gold nanoparticles (GNPs) has received much attention for their easy application. Most of the current methods involve known protocols which employ toxic chemicals and hazardous byproducts. This greatly limits their use in biomedical fields, particularly in clinical applications. Recent research has been focused on gre...

background: gold nanoparticles (gnps) have been shown as a good radiosensitizer. in combination with radiotherapy, several studies with orthovoltage x-rays have shown considerable dose enhancement effects. this paper reports the dose enhancement factor (def) due to gnps in 18 megavoltage (mv) beams. materials and methods: different geometrical 50-nm gnps configurations at a concentration of 5 m...

Hollow sea-urchin gold nanoparticles (HSU-GNPs) were successfully prepared through a novel one-step galvanic replacement strategy, and their corresponding optical properties was studied in detail. During the synthesis process, the sizes of the interior hollows of the HSU-GNPs could be changed by adjusting the amount of silver nitrate added into hydrogen tetrachloroaurate trihydrate solution. Th...

Nanotechnology has provided many promising nanoplatforms for targeted cancer imaging and therapy. Among these platforms, gold nanoparticles (GNPs) play a unique role in medicine because of their excellent physical and chemical properties. To expand the applications of GNPs in medicine, amounts of targeting moieties, imaging labels, and therapeutic agents have been integrated into these particle...