Glycyrrhizic acid (GA) is a triterpene glycoside found in the roots of licorice plants (Glycyrrhiza glabra). GA is the most important active ingredient in the licorice root, and possesses a wide range of pharmacological and biological activities. GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and antiallergic...

An ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-qTOF-MS/MS) method was developed and validated for the simultaneous determination of glycyrrhizin and glycyrrhetic acid. These analytes were separated on a reverse phase C18 column using a mobile phase of acetonitrile:2% acetic acid in water (75:25, v/v) with a flow rate of 200 μL/min. The qTOF-MS was o...

Licorice extract has long been known as a natural sweetener and thirst reliever. Many people who take large amounts are prone to complications overestimate its nutritional benefits. Glycyrrhetic acid, the active metabolite in licorice, inhibits 11-ß-hydroxysteroid dehydrogenase enzyme type 2 causing increased cortisol levels hypernatremia, hypokalemia. In this case report, we ensure holistic st...