Increased emphasis on strict glycaemic control of insulin dependent diabetes mellitus (IDDM) in young patients may be expected to cause increases in rates of significant hypoglycaemia. To evaluate whether this is the case for a large population based sample of IDDM children and adolescents rates of severe (coma, convulsion) and moderate (requiring assistance for treatment) hypoglycaemia were st...

BACKGROUND Glycated haemoglobin or glycosylated haemoglobin (HbA1c) is a form of haemoglobin that is measured primarily to identify the average plasma glucose concentration over prolonged periods of time. Levels of HbA1c represent the average blood glucose levels of diabetic patients over the previous 120 days. The objective of this study was to see the correlation between HbA1c levels and rand...

OBJECTIVE To assess the sociodemographic patterning of changes in glycaemic control of patients with diabetes affected by the 2011 triple disaster in Japan (earthquake, tsunami and nuclear accident). METHODS A retrospective cohort study was undertaken with 404 patients with diabetes at a public hospital in Minamisoma City, Fukushima Prefecture. Glycated haemoglobin (HbA1c) levels were measure...

BACKGROUND The A1c-derived average glucose examined the link between the glycated haemoglobin and the estimated average glucose, and provided a linear relation between them. Other studies proved that, over a period of 4 months, plasma glucose in the preceding 30 days contribute to about 50 % to the glycated haemoglobin value while the other 50 % is due to the remaining 3 months altogether. TE...

We investigated the in vivo and in vitro effects of aspirin on several clinical assays of glycosylated hemoglobin. Acetylation of hemoglobin falsely increased the glycosylated hemoglobin fraction measured by "high-performance" liquid chromatography and electrophoresis, but isoelectric focusing and colorimetric techniques differentiated between acetylated and glycosylated fractions. Aspirin inge...

Therefore, it was somewhat surprising to find a normal, rather than very above-normal, concentration of glycosylated hemoglobin associated with a highly negatively charged fast hemoglobin variant. This patient was heterozygous for a fast hemoglobin variant; the high proportion of the variant hemoglobin (50%) and the lack of an abnormal HbA2 by cellulose acetate electrophoresis suggest a mutatio...

back ground: nowadays diabetes is considered as the most common metabolic disorder and an important cause of morbidity and mortality worldwide. diabetes has not definitive treatment but the progression of the disease and its related complication could be prevented properly by proper diet. the aim of current study is to determine the relation between fruit and vegetable consumption and physical ...

We investigated the effect of temperature, variant hemoglobins, and hyperlipidemia on determination of glycosylated hemoglobin by an electrophoretic method (Clin. Chem. 26: 1598-1602, 1980). We found that: (a) temperature variations ranging from 4 to 30 degrees C were without effect on results obtained by electrophoresis; (b) concurrent determination of glycosylated hemoglobin by electrophoresi...