OBJECTIVE Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized. RESEARCH DESIGN AND METHODS In this study, 36 type 1 diabetic patients and 12 control subjects were enrolled. The diabetic patients were divided into three groups. The first group was treated for 24 h with insul...

Maturity-onset diabetes of the young (MODY) is characterized by an autosomal dominant mode of inheritance, early onset of hyperglycemia, and defects of insulin secretion. MODY subtypes described present genetic, metabolic, and clinical differences. MODY 2 is characterized by mild asymptomatic fasting hyperglycemia, and rarely requires pharmacological treatment. Hence, precise diagnosis of MODY ...

BACKGROUND Early screening of type 2 diabetes mellitus (DM) is essential for improved prognosis and effective delay of clinical complications. However, testing for high glycemia often requires invasive and painful blood testing, limiting its large-scale applicability. We have combined new, unpublished data with published data comparing salivary glucose levels in type 2 DM patients and controls ...

A 80-year-old man was regularly surveyed in our service since 1987 for a relapsing polychondritis and treated with Dapsone, 100 mg per day, with a good outcome on chondritis. During the follow-up, a prostate carcinoma was diagnosed in 1990 and treated with surgery and brachytherapy. An in situ bladder carcinoma was treated in 1997 with BCG therapy. Both carcinomas were regularly surveyed and re...