Protective action of Livol (a herbal formulation) against paracetamol induced experimental hepatotoxicity was observed in dog. Increased values of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum total cholesterol and its fractions, globulin, icterus index, prothrombin time and bromosulphalein retention by paracetamol (250 mg/kg, once orally) were decrease...

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

Objective(s):  There is a rising use of gold nanoparticles (AuNPs) in goods and in the medical fields but there is concern about the toxicity of them. So in this study spherical AuNPs with 3 different concentrations were applied for investigating their effects in vivo.   Materials and Methods:  40 male albino mice were randomly divided into sham, control, 25 ppm, 50 ppm, 100 ppm groups and were...

This study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of Lippia nodiflora (MELN) in acute experimental liver injury induced by paracetamol (750mg/kg, b.w). MELN at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transamina...

The role of glutamate transporters in the regulation of synaptic depression was examined in the avian nucleus magnocellularis. Repetitive stimulation of presynaptic auditory nerve fibers resulted in acute depression of EPSCs. Pharmacological blockade of glutamate transport in glial cells enhanced residual glutamate in the synaptic cleft and markedly increased the extent of depression at stimulu...

objective(s):  there is a rising use of gold nanoparticles (aunps) in goods and in the medical fields but there is concern about the toxicity of them. so in this study spherical aunps with 3 different concentrations were applied for investigating their effects in vivo.   materials and methods:  40 male albino mice were randomly divided into sham, control, 25 ppm, 50 ppm, 100 ppm groups and were...

The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanol extract of Berberis tinctoria Lesch (Berberidaceae) leaves was investigated for its hepatoprotective and antioxidant effects on paracetamol (750 mg/kg) induced acute liver damage in Wistar albino rats. Hepa...

In the present study, Citrus maxima essential crude oil extract was used to prepare combinatorial formulations and workers of Indian white termite Odontotermes obesus were treated topically with 40% 80% 24 hr LD50 values these formulations. subsequent bioassays levels various enzymes i.e. alkaline phosphatase, acid glutamate oxaloacetate transaminase, pyruvate transaminase acetylcholinesterase ...

Activ~ties of lactic dehydrogenase (LDH), glutamate oxaloacetate transanunase (GOT) and glutamate pyruvate transaminase (GPT) were measured in blood plasma and some tissues of grey mullet Mugd auratus Risso. After determination of optimal assay conditions, cardiac sampling for LDH estimation was recommended. Tissue distribution of enzymers and their origln in plasma were described, in particula...

Objective: Hepatoprotective activity of Punica granatum Linn. (Family: Punicaceae) was evaluated by in vitro and in vivo model. HepG2 cell lines were used for in vitro study and D-Galactosamine (D-GalN) induced hepatic damage model for in vivo evaluation. Methods: Hepatoprotective potential was assessed by measuring serum level of glutamate oxaloacetate transaminase, glutamate pyruvate transami...