Glucose transport by jejunal mucosa in vitro and kidney in vivo was investigated in a 3 yr old patient with congenital glucose-galactose malabsorption, her family, and 16 normal volunteers. Glucose transport by normal human jejunal mucosa was concentrative, saturable, sodium and energy dependent, and exhibited competitive inhibition. Biopsy specimens from six normal controls and an asymptomatic...

A B S T R A C T Both galactose accumulation and phlorizin binding by columnar epithelial cells have been investigated in vitro with a recently developed technique for high-resolution, plastic-section radioautography which is particularly suited to small quantities of biopsy tissue. Grain density analysis of the radioautographs provides definitive support for the view that the cellular mechanism...

A major focus in studies of multivariate evolution is on trying to understand the biological and evolutionary forces that shape patterns of covariance between organismal traits. This is particularly truewith respect to studies concerned with the topics of phenotypic integration and modularity (see Chernoff and Magwene 1999, for a review). In a recent paper published in Systematic Biology on the...

Five patients with sucrase-isomaltase deficiency, and one patient with primary glucose-galactose malabsorption had no increases in breath hydrogen excretion after oral sucrose or glucose. Anaerobic incubation with sugars of stool suspensions from 5 patients with primary sugar malabsorption produced by trace of hydrogen (17 microliter) in only one, while those from 13 or 14 controls produced a m...

originally to do the work that developed methods for isolation of highly purified brush-border membranes from biopsy specimens as small as 10-15mg (Schmitz et al., 1973). In one early test, we found no difference in the banding pattern on gel electrophoresis between the brush-border membrane of a normal and a glucose-galactose-malabsorption biopsy. However, our further studies of reconstitution...

A five-month-old Indian girl, product of consanguineous marriage, presented with diarrhoea with an onset within two days after birth, severe malnutrition and metabolic acidosis. The diarrhoea persisted even with lactose-free formula, amino acid-based formula and glucose-containing oral rehydration solution, but stopped when fasted. She required prolonged parenteral nutrition. Fructose and gluco...