نتایج جستجو برای: glanzmann
تعداد نتایج: 297 فیلتر نتایج به سال:
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Glanzmann thrombasthenia is an autosomal recessive bleeding disorder characterized by a life-long hemorrhagic tendency and absent or severely reduced platelet aggregation in response to agonists. The thrombasthenic phenotype is associated with quantitative or qualitative abnormalities in the platelet fibrinogen receptor, the αIIbβ3 integrin or glycoprotein (GP) IIb-IIIa, which can also serve as...
OBJECTIVE To describe the clinical presentation of patients with Glanzmann's thrombasthenia (GT) and evaluate their diagnostic, clinical, and laboratory parameters including platelet aggregometry. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Hematology and Blood Transfusion, The Children Hospital and Institute of Child Health, Lahore, from January 2006 to Decemb...
Background: Glanzmanns Thrombasthenia (GT) is a GPIIb/IIIa platelet surface receptor condition that defined by lack of aggregation, either qualitatively or quantitatively. This receptors physiological function to bind various sticky plasma proteins aid adhesion and ensuring the development thrombus at sites vascular damage. Patient GT typically presents with menorrhagia, easy bruising, epistaxi...
Glanzmann thrombasthenia is a rare bleeding disorder that can present life-threatening bleeding. Our patients develop antiplatelet antibodies that become refractory to any pharmacological treatment. Allogeneic hematopoietic stem-cell transplantation is the only currently curative procedure, but has major risks mainly in adult; indeed, our patient died.
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