background: oral manifestations are frequently the initial signs of acute leukemia, prompting the patient to consult the dentist first. the gingival tissue is one site commonly involved either by leukemic infiltration or by inflammatory reactive hyperplasia, causing gingival enlargement. the gingival infiltration may also be present without gingival enlargement. early recognition of clinical fi...

With the advent of effective drug therapy, tuberculous lesions of the oral cavity have become so rare that they are frequently forgotten. Primary gingival tuberculosis is extremely rare and usually manifests as ulcer. We report the first case of primary tuberculosis manifesting as gingival enlargement, which was the only presenting sign of tuberculosis. Diagnosis was based on histopathology (he...

The purpose of this article is to report a case of unusual oral contraceptive induced periodontal endocrinopathies and its treatment approach. A 32-year-old female patient, having fair oral hygiene, presented with painless, soft, diffuse gingival enlargement on severely compromised periodontium (⩾ 4 mm generalized alveolar bone loss and attachment loss). The patient had on oral contraceptive ov...

OBJECTIVES Side effect of medicamentous treatment in hypertension therapy and angina pectoris with calcium channel blockers related to fibrotic gingival enlargement were examined. METHODS In our study we deal with clinico-histopathological and microbiological knowledge from this field underpinned by two case reports treated with antihypertensive therapy using calcium channel blockers. In the ...

The three most common classes of medications implicated in drug-induced gum enlargement are anticonvulsives, calcineurin inhibitors, and calcium channel blockers. Treatment primarily consists of withdrawing the offending agent whenever possible, in addition to maintaining good oral hygiene. Gingivectomy or flap surgery may be needed in resistant cases.

The homeostasis of the periodontium involves complex multifactorial relationships, in which the endocrine system plays an important role [1]. Hormones are specific regulatory molecules that modulate function reproduction, growth and development and the maintenance of internal environments as well as energy production, utilization and storage [1]. As well as being the regulators of reproductive ...

objective: the aim of the present study was to investigate the level of gingival over-growth (go) in patients with kidney transplant. materials and methods: the target group of the study was the patients recently received kidney transplant and cyclosporine-a therapy. by a systematic case selection method, a total of 131 cases were included in the study, of whom 80 (61.6%) patients were male. th...

OBJECTIVE To study the expression and role in vigabatrin (VGB)-induced gingival enlargement of Ki-67 antigen and p27KIP1, p21WAF1, and p53, proteins that activate or inhibit cell-cycle progression. MATERIALS AND METHODS Six patients treated with VGB for partial epileptic seizures refractory to classic anticonvulsant treatment were studied. Gingival biopsies were taken from four of these patie...

BACKGROUND Inflammatory gingival enlargement is a common observation in routine dental practice. Drugs like nifedipine, used for hypertension and Porphyromonas gingivalis infection-induced gingival enlargement is of a major concern. The current study aims to identify the inflammatory response of the gingival enlargement by measuring the major inflammatory markers fibrinogen and C-reactive prote...

Epilepsy is a common neurological disorder with recurrent seizures due to a chronic underlying process. Despite tremendous advances in the field of understanding regarding the etio-pathogenesis of epilepsy, phenytoin still remains the drug of choice in its management. Chronic administration of phenytoin has been associated to have a number of adverse effects. Gingival enlargement is one such mo...