A 67-year-old woman had a large mediastinal mass with calcification. On roentgenogram of 30 years ago, the same mass without calcification was seen. The mediastinal mass was removed by surgery and proved to be a non-Hodgkin's lymphoma (NHL), most probably as a transition from a giant lymph node hyperplasia (Castleman's disease).

Castleman and Towne described a disease presenting as a mediastinal mass resembling thymoma. It is also known as "giant lymph node hyperplasia", "lymph node hamartoma", "angiofollicular mediastinal lymph node hyperplasia", and "angiomatous lymphoid hyperplasia". The pathogenesis is unknown, but the bulk of evidence points toward faulty immune regulation, resulting in excessive B-lymphocyte and ...

Castleman disease (CD), also known as angiofollicular lymph node hyperplasia and giant lymph node hyperplasia, was first described in 1956 by Dr. Benjamin Castleman as localized mediastinal lymph node proliferation. Nodal hyperplasia has been described as hyaline vascular (80–90%), plasma cell (10–20%), and mixed.1 CD is a rare disease with no racial or sex predominance.2 Clinical characteristi...

Giant lymph node hyperplasia (Castleman's Disease) is a rare cause of pleural effusion. We report the case of a 51 yr old West Indian male, who presented with a recurrent massive pleural effusion, due to a tumour arising from the pleura. He underwent parietal pleurectomy and subtotal excision of the tumour. Histological analysis of the specimen showed the features of multicentric Castleman's di...

lymph node dissection is of prime importance for accurate staging of colorectal carcinomas. since a great number of small lymph nodes are missed in the traditional method, several fat clearing solutions have been introduced for easier detection of smaller lymph nodes. in this study we evaluated the efficacy of a new fat clearing solution so-called lymph node revealing solution (lnrs) in colecto...

background: sentinel lymph node biopsy (slnb) has replaced axillary lymph node dissection (alnd) in early breast cancer patients as the first line surgical approach to axillary nodes. further dissection is performed only when sln is involved by tumor cells. however, in a significant proportion of patients, non-sentinel nodes are still not involved and axillary dissection has no additional thera...