background: the aim of this study was to quantify the number of mast cells in focal reactive hyperplastic lesions of the oral cavity and to compare these two number of mast cells in normal gingival tissues and to correlate their presence with the state of connective tissue changes in reactive lesions and probably suggest a role for mast cells in these lesions. materials and methods: patient rec...

Introduction: It is well-recognized that cells of the monocyte/macrophage lineage are capable of fusion to form multinucleated giant cells (MGCs). The presence of multinucleated giant cells on FNAC smears of breast lumps have been described only sporadically in the literature. As this is a common specimen in Cytopathology, knowledge of frequency of this variation can be valuable to cytopatholog...

Case Description- A pigeon with an abnormal mass on right wing was referred to the Veterinary Clinic of Shahid Bahonar University of Kerman. Treatment and Outcome- The mass was removed surgically and histopathologic examination was done. Microscopic findings revealed a stori-form pattern of atypical and pleomorphic spindle-shape tumor cells with histiocytes and too many thick wall capillari...

Introduction: Multinucleated giant cells are often encountered in oral lesions. An understanding of the histogenesis of these giant cells can give us an insight on the pathologic process in progress. Traditional classifications have placed little importance on the type or histogenesis of multinucleated giant cells in grouping these lesions. Objectives: (a) To classify giant cell lesions based o...

central giant cell granuloma (cgcg) is a benign proliferation of fibroblasts and multinucleated giant cells that almost exclusively occurs in the jaws. it commonly occurs in young adults showing a female predilection in the anterior mandible. multifocal cgcgs in maxillofacial region are very rare and suggestive of systemic diseases such as hyperparathyroidism, an inherited syndrome such as noon...

Amyloidoma or amyloid tumor is a tumor-like localized deposit of amyloid encountered occasionally in association with multiple myeloma, various chronic inflammatory diseases and primary amyloidosis. Amyloid tumors unassociated with plasmacytoma or other disease are extremely rare in soft tissues and few cases in various situations have been reported. Histologic examination discloses amorp...

Giant cell myocarditis is a serious and frequently fatal inflammatory heart disease of which the etiology remains unknown. In the present study, we investigated the origin of multinucleated giant cells in myocarditis with the use of an experimental model. We also examined the factors relating to the formation of giant cells in myocarditis. Severe myocarditis characterized by the appearance of m...

INTRODUCTION Oral peripheral and central giant cell granulomas are lesions with little-known etiology and pathogenesis. OBJECTIVE The aim of this study was to compare matrix metalloproteinases-2 and osteopontin protein expression in the multinucleated giant cells and mononuclear cells of the peripheral and central giant cell granuloma lesions. METHODS In this retrospective study, the presen...