Background: Integrity of the tight junction (TJ) which seals the gap between the epithelial cells of the gastrointestinal tract is critical in preventing the entry of the microbial toxins, antigens, and other harmful products in the subepithelial tissues and the internal milieu. By enabling the absorption of these products, impairment of the intestinal epithelial barrier leads to local and syst...

Vaziri, N. D. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am J Physiol Renal Physiol 290: F262–F272, 2006; doi:10.1152/ajprenal.00099.2005.—Chronic renal failure (CRF) results in profound lipid disorders, which stem largely from dysregulation of high-density lipoprotein (HDL) and triglyceride-rich lipoprotein metabolism. Specifically, maturation of...

Oral lichen planus (OLP) is a common chronic inflammatory oral disorder. A number of studies have shown that OLP has a malignant potential: the rate of malignant transformation in OLP has been reported to be between 0.4 and 5.6% over ten years (Abbate et al., 2006). The WHO considers OLP to be a premalignant condition (Holmstrup, 1992). Human telomeres are regions of tandem (TTAGGG)n repeats at...

[*] Prof. K. H. Oh, S. S. Oh, D. H. Kim, Prof. M. Kim, Prof. E. Yoon Department of Materials Science and Engineering, Seoul National University Seoul, 151-744 (Korea) E-mail: [email protected] Prof. J. W. Hutchinson, Dr. M. -W. Moon, Dr. A. Vaziri School of Engineering and Applied Sciences, Harvard University Cambridge, MA 02138 (USA) E-mail: [email protected] Dr. M. -W. Moon Future F...

Hydrogen sulphide, H(2)S, is a gaseous compound involved in a number of biological responses, e.g. blood pressure, vascular function and energy metabolism. In particular, H(2)S is able to lower blood pressure, protect from injury in models of ischaemia-reperfusion and induce a hypometabolic state. In chronic kidney disease (CKD), low plasma hydrogen sulphide levels have been established in huma...

We have recently shown that erythropoietin (EPO)-induced hypertension is unrelated to the rise in hematocrit and is marked by elevated cytosolic [Ca] and nitric oxide (NO) resistance. The present study was done to determine the effect of EPO on NO production and endothelial NO synthase (eNOS) expression by endothelial cells. Human coronary artery endothelial cells were cultured to subconfluence...

1. Harrison, D.E. & Astle, C.M. Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure. J. Exp. Med. 156, 1767–1779 (1982). 2. Bodnar, A.G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349–352 (1998). 3. Vaziri, H. et al. Evidence for a mitotic clock in human hematopoietic...

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background: despite the fact that being exposed to traumatic and stressful events could have severe consequences, studies have shown that even in the wake of negative events such as cancer diagnosis, we see some changes and positive impacts in scheme, philosophy of life and self-perception, a process which is called post traumatic growth (ptg). the aim of the current research is to define share...